Abstract | BACKGROUND: Podoplanin (PDPN) is a sialylated membrane glycoprotein that binds to C-type lectin-like receptor 2 on platelets resulting in platelet activation. PDPN is expressed on lymphatic endothelial cells, perivascular fibroblasts/pericytes, cancer cells, cancer-associated fibroblasts, and tumor stromal cells. PDPN's expression on malignant epithelial cells plays a role in metastasis. Furthermore, the expression of PDPN in brain tumors (high-grade gliomas) was found to correlate with an increased risk of venous thrombosis. OBJECTIVE: METHODS: RESULTS: CONCLUSIONS:
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Authors | Tomoyuki Sasano, Ricardo Gonzalez-Delgado, Nina M Muñoz, Wendolyn Carlos-Alcade, Min Soon Cho, Rahul A Sheth, Anil K Sood, Vahid Afshar-Kharghan |
Journal | Journal of thrombosis and haemostasis : JTH
(J Thromb Haemost)
Vol. 20
Issue 1
Pg. 104-114
(01 2022)
ISSN: 1538-7836 [Electronic] England |
PMID | 34608736
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | © 2021 International Society on Thrombosis and Haemostasis. |
Topics |
- Animals
- Disease Models, Animal
- Endothelial Cells
- Glioma
- Mice
- Ovarian Neoplasms
- Platelet Aggregation
- Venous Thrombosis
(genetics)
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