A systematic review and meta-analysis of the efficacy of topical sphincterotomy treatments for anal fissure.

Abstract

BACKGROUND:

Anal fissure is a common condition that can be treated medically or surgically. Chemical sphincterotomy is often used before surgical intervention. This study aims to evaluate the effectiveness of topical agents for chemical sphincterotomy on healing of anal fissures and side-effects.

METHODS:

A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) compliant systematic review was performed using MEDLINE, EMBASE, Scopus, and CENTRAL databases. Eligible studies included randomized controlled trials which compared topical sphincterotomy agents with topical placebo agents or each other. Studies that included surgical treatments were excluded. Overall evidence was synthesized according to the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach.

RESULTS:

Thirty-seven studies met the study selection criteria. Seventeen studies show that glyceryl trinitrate (GTN) was significantly more likely to heal anal fissure than placebo (relative risk (RR) = 1.96, 95% confidence interval (95%CI) = 1.35-2.84, I2 = 80%). Eleven studies showed a marginally significant difference between healing rates for diltiazem vs GTN, RR = 1.16, (1.01-1.33) I2 = 48%. There was no significant difference in healing between diltiazem and placebo, RR = 1.65, (0.64-4.23), I2 = 92%. GTN significantly reduced pain on the visual analog scale compared to the placebo group, MD-0.97 (-1.64 to -0.29) I2 = 92%. There was high certainty of evidence that GTN was significantly more likely to cause headache than placebo (RR = 2.73 (1.82-4.10) I2 = 58%) and diltiazem RR = 6.88 (2.19-21.63) I2 = 17%.

CONCLUSION:

There is low certainty evidence topical nitrates are an effective treatment for anal fissure healing and pain reduction compared to placebo. Despite widespread use of topical diltiazem, more evidence is required to establish the effectiveness of calcium channel blockers compared to placebo.

• Authors: James Z Jin, Molly-Olivia Hardy, Hanson Unasa, Melbourne Mauiliu-Wallis, Maree Weston, Andrew Connolly, Primal Parry Singh, Andrew G Hill
• Journal: International journal of colorectal disease (Int J Colorectal Dis) Vol. 37 Issue 1 Pg. 1-15 (Jan 2022) ISSN: 1432-1262 [Electronic] Germany
• PMID: 34608561 (Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
• Copyright: © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Chemical References

• Vasodilator Agents
• Diltiazem
• Nitroglycerin

Topics

• Administration, Topical
• Chronic Disease
• Diltiazem (therapeutic use)
• Fissure in Ano (drug therapy, surgery)
• Humans
• Nitroglycerin (therapeutic use)
• Sphincterotomy
• Treatment Outcome
• Vasodilator Agents (therapeutic use)