Chronic bioassay of benzyl chloride in F344 rats and (C57BL/6J x BALB/c)F1 mice.

Abstract

Benzyl chloride was administered to groups of 52 male and 52 female F344 rats and (C57BL/6J x BALB/c)F1 mice at two dose levels by gavage in corn oil three times a week for 2 years. Survivors were sacrificed a few weeks later and examined histopathologically. On the basis of a subchronic study at a range of doses, the doses of benzyl chloride in the chronic study were 100 and 50 mg/kg body weight for mice and 30 and 15 mg/kg body weight for rats. In mice of both sexes there was a high and statistically significant incidence of carcinomas and papillomas of the forestomach. In the livers of male mice, but not of females, there was a significantly increased incidence of hepatocellular neoplasms at the low dose but not at the maximally tolerated dose (MTD). In rats the only neoplasms showing a statistically significant increase compared with controls were C-cell neoplasms of the thyroid gland in females. A significant incidence of neoplasms was not found in the forestomachs of F344 rats, but it is possible that true MTD was not used for rats.

• Authors: W Lijinsky
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 76 Issue 6 Pg. 1231-6 (Jun 1986) ISSN: 0027-8874 [Print] United States
• PMID: 3458959 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Benzyl Compounds
• benzyl chloride

Topics

• Animals
• Benzyl Compounds (analysis)
• Body Weight (drug effects)
• Carcinoma (chemically induced)
• Dose-Response Relationship, Drug
• Female
• Male
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C57BL
• Neoplasms, Experimental (chemically induced)
• Papilloma (chemically induced)
• Rats
• Rats, Inbred F344
• Sex Factors
• Stomach Neoplasms (chemically induced)