A prediction model based on platelet parameters, lipid levels, and angiographic characteristics to predict in-stent restenosis in coronary artery disease patients implanted with drug-eluting stents.

Abstract

BACKGROUND:

The present study was aimed to establish a prediction model for in-stent restenosis (ISR) in subjects who had undergone percutaneous coronary intervention (PCI) with drug-eluting stents (DESs).

MATERIALS AND METHODS:

A retrospective cohort study was conducted. From September 2010 to September 2013, we included 968 subjects who had received coronary follow-up angiography after primary PCI. The logistic regression analysis, receiver operator characteristic (ROC) analysis, nomogram analysis, Hosmer-Lemeshow χ2 statistic, and calibration curve were applied to build and evaluate the prediction model.

RESULTS:

Fifty-six patients (5.79%) occurred ISR. The platelet distribution width (PDW), total cholesterol (TC), systolic blood pressure (SBP), low-density lipoprotein cholesterol (LDL-C), and lesion vessels had significant differences between ISR and non-ISR groups (all P < 0.05). And these variables were independently associated with ISR (all P < 0.05). Furthermore, they were identified as predictors (all AUC > 0.5 and P < 0.05) to establish a prediction model. The prediction model showed a good value of area under curve (AUC) (95%CI): 0.72 (0.64-0.80), and its optimized cut-off was 6.39 with 71% sensitivity and 65% specificity to predict ISR.

CONCLUSION:

The incidence of ISR is 5.79% in CAD patients with DES implantation in the Xinjiang population, China. The prediction model based on PDW, SBP, TC, LDL-C, and lesion vessels was an effective model to predict ISR in CAD patients with DESs implantation.

• Authors: Min-Tao Gai, Bing Zhu, Xiao-Cui Chen, Fen Liu, Xiang Xie, Xiao-Ming Gao, Xiang Ma, Zhen-Yan Fu, Yi-Tong Ma, Bang-Dang Chen
• Journal: Lipids in health and disease (Lipids Health Dis) Vol. 20 Issue 1 Pg. 118 (Sep 29 2021) ISSN: 1476-511X [Electronic] England
• PMID: 34587955 (Publication Type: Journal Article)
• Copyright: © 2021. The Author(s).

Chemical References

• Lipids

Topics

• Aged
• Angiography (methods)
• Blood Platelets (metabolism)
• Calibration
• Coronary Artery Disease (blood, diagnosis)
• Coronary Restenosis
• Drug-Eluting Stents (adverse effects)
• Female
• Humans
• Lipids (blood)
• Male
• Middle Aged
• Models, Statistical
• Multivariate Analysis
• Nomograms
• ROC Curve
• Regression Analysis
• Retrospective Studies
• Risk