[Pterocarpans and their biological activities: a review].

Abstract

Pterocarpans, ubiquitous in Fabaceae, are protective active substances produced by the chemical defense system of plants. A total of 144 pterocarpans had been discovered before 2006. For the first time, we reported the 89 pterocarpans identified in 2006-2020. These pterocarpans not only demonstrate novel complex diversified genus-specific stereostructures but also display strong anti-microbial, anti-tumor, antioxidant, insecticidal, and anti-inflammatory activities. Through the projection of their biogenetic pathways and study of the pharmacological activities, the structure-activity correlation was further confirmed. The distribution of Leguminosae plants rich in pterocarpans has obvious regional characteristics. Therefore, the research and utilization of Leguminosae plant resources in China should be strengthened, and the popularity and application value of the geographical indicator plant resources should be improved. This paper serves as a reference for further research, development, and utilization of pterocarpans and their plant sources.

• Authors: Xin-Ping Huang
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 46 Issue 17 Pg. 4323-4333 (Sep 2021) ISSN: 1001-5302 [Print] China
• PMID: 34581035 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Inflammatory Agents
• Antioxidants
• Plant Extracts
• Pterocarpans

Topics

• Anti-Inflammatory Agents
• Antioxidants
• Fabaceae
• Plant Extracts (pharmacology)
• Pterocarpans (pharmacology)