Pterocarpans

A group of compounds which can be described as benzo-pyrano-furano-benzenes which can be formed from ISOFLAVONES by internal coupling of the B ring to the 4-ketone position. Members include medicarpin, phaseolin, and pisatin which are found in FABACEAE.

Networked: 16 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Pessoa, Cláudia: 3 articles (01/2021 - 04/2006)
2.	Costa, Paulo R R: 2 articles (01/2021 - 02/2009)
3.	Costa-Lotufo, Letícia V: 2 articles (09/2014 - 04/2006)
4.	Lima, Mary Anne S: 2 articles (09/2014 - 04/2006)
5.	Militão, Gardenia C G: 2 articles (09/2014 - 04/2006)
6.	Silveira, Edilberto R: 2 articles (09/2014 - 04/2006)
7.	Huang, Xin-Ping: 1 article (09/2021)
8.	Barcellos, Júlio C F: 1 article (01/2021)
9.	Claudia Dos Santos Luciano, Maria: 1 article (01/2021)
10.	Domingos, Jorge L O: 1 article (01/2021)

Related Diseases

1.	Leukemia 04/11/2006 - "Induction of apoptosis by pterocarpans from Platymiscium floribundum in HL-60 human leukemia cells." 04/11/2006 - "The purpose of the present study was to examine whether induction of apoptosis and/or inhibition of DNA synthesis is involved in the cytotoxicity of these pterocarpans in human leukemia cells. " 02/01/2009 - "Naturally occurring pterocarpans 1a,b, pterocarpan 1c, isoflavane 2 and ortho-quinone 3 were synthesized in the racemic form and their cytotoxic effect was evaluated on the human leukemia cell lines K562 (resistant to oxidative stress), Lucena-1 (MDR phenotype) and HL-60. " 03/10/2017 - "Recently, pterocarpans gained lot of attention because of the broad range of anti-cancer activities in various cancer cell lines such as breast, leukemia, cervical, lung, colon and melanoma. "
2.	Neoplasms (Cancer) 01/01/2023 - "The isoflavonoid derivatives, pterocarpans and coumestans, are explored for multiple clinical applications as osteo-regenerative, neuroprotective and anti-cancer agents. " 01/01/2021 - "New 5-carba-pterocarpans: Synthesis and preliminary antiproliferative activity on a panel of human cancer cells." 01/01/2020 - "Prenylated pterocarpans 1-3 prevented the cell cycle progression of human cancer cells in S-phase. " 09/01/2014 - "Pterocarpans induce tumor cell death through persistent mitotic arrest during prometaphase." 09/01/2021 - "These pterocarpans not only demonstrate novel complex diversified genus-specific stereostructures but also display strong anti-microbial, anti-tumor, antioxidant, insecticidal, and anti-inflammatory activities. "
3.	Melanoma (Melanoma, Malignant) 03/10/2017 - "Recently, pterocarpans gained lot of attention because of the broad range of anti-cancer activities in various cancer cell lines such as breast, leukemia, cervical, lung, colon and melanoma. " 05/15/2008 - "Several classes of flavonoids [flavanoids (1-10), flavonol (11), isoflavones (12-18), isoflavanones (19-22), isoflavans (23-26), chalcones (27-30), auronol (31), pterocarpans (32-37), 2-arylbenzofuran (38), and neoflavonoid (39)] and lignans (40-42) isolated from the MeOH extract of Brazilian red propolis were investigated for their cytotoxic activity against a panel of six different cancer cell lines including murine colon 26-L5 carcinoma, murine B16-BL6 melanoma, murine Lewis lung carcinoma, human lung A549 adenocarcinoma, human cervix HeLa adenocarcinoma, and human HT-1080 fibrosarcoma cell lines. "
4.	Lewis Lung Carcinoma 05/15/2008 - "Several classes of flavonoids [flavanoids (1-10), flavonol (11), isoflavones (12-18), isoflavanones (19-22), isoflavans (23-26), chalcones (27-30), auronol (31), pterocarpans (32-37), 2-arylbenzofuran (38), and neoflavonoid (39)] and lignans (40-42) isolated from the MeOH extract of Brazilian red propolis were investigated for their cytotoxic activity against a panel of six different cancer cell lines including murine colon 26-L5 carcinoma, murine B16-BL6 melanoma, murine Lewis lung carcinoma, human lung A549 adenocarcinoma, human cervix HeLa adenocarcinoma, and human HT-1080 fibrosarcoma cell lines. "
5.	Osteoporosis 01/01/2017 - "A series of new 6H-benzofuro[3, 2-c]chromenes (BFC, pterocarpans) with structure-activity relationships were investigated for their potential use in osteoporosis treatment. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Isoflavones
3.	Antioxidants
4.	Flavones
5.	Chalcones
6.	Lignans
7.	Propolis (Bee Bread)
8.	Flavonoids
9.	Esters
10.	Benzopyrans

Related Therapies and Procedures

1.	Lasers (Laser)