Comparative study of an antimicrobial peptide and a neuropeptide conjugated with gold nanorods for the targeted photothermal killing of bacteria.

Abstract

There are certain disadvantages in treating bacterial infections through conventional methods. For this reason, the current study does focus on combating bacterial wound infections by photothermal therapy assisted by gold nanorod-peptide conjugates (GNR-peptide conjugates). Two peptides, the cationic antimicrobial peptide LL-37 and neuropeptide ANGIOPEP-2 both with specificity for targeted bacterial binding, were conjugated with GNR surface through electrostatic interactions. The GNR-peptide conjugates showed good biocompatibility, sufficient stability, enhanced targeting, potential photothermal killing of bacteria, and possible acceleration of wound healing. The photo-biomodulation properties of NIR improved the wound closure rates through enhanced cell migration. The multifunctional LL37-conjugated GNRs significantly enhanced photothermal therapeutic outcomes based on bacterial targeting with promising wound healing properties.

• Authors: Sivasoorian Siva Sankari, Hans-Uwe Dahms, Ming-Fong Tsai, Yu-Lun Lo, Li-Fang Wang
• Journal: Colloids and surfaces. B, Biointerfaces (Colloids Surf B Biointerfaces) Vol. 208 Pg. 112117 (Dec 2021) ISSN: 1873-4367 [Electronic] Netherlands
• PMID: 34564040 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 Elsevier B.V. All rights reserved.

Chemical References

• Neuropeptides
• Pore Forming Cytotoxic Proteins
• Gold

Topics

• Bacteria
• Gold
• Nanotubes
• Neuropeptides
• Pore Forming Cytotoxic Proteins