Comparison of risk scores in predicting symptomatic intracerebral hemorrhage after endovascular thrombectomy.

Abstract

BACKGROUND/PURPOSE:

Several risk scores have been developed to predict symptomatic intracerebral hemorrhage (SICH) after acute reperfusion therapy for ischemic stroke. We compared the performance of established risk scores in predicting SICH after EVT under different SICH criteria.

METHODS:

A total of 258 patients with anterior circulation large vessel occlusion who received EVT in two medical centers of Taiwan were recruited. Three definitions of SICH, the European Collaborative Acute Stroke Study II (ECASS II), ECASS III, and the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST), were used. The HAT, SITS-SICH, SEDAN, and TAG risk scores were applied. Logistic regression and area under the receiver operating characteristic curve (AUC) were used to evaluate the performance of each risk model.

RESULTS:

In the 258 included patients (mean age, 71.9 ± 11.8 years; men, 48.1%), the observed rates of SICH according to ECASS II, ECASS III, and SITS-MOST criteria were 10.1%, 5.0%, and 4.7%, respectively. Higher glucose level (>160 mg/dL) and unsuccessful recanalization independently predicted SICH under all criteria. Among the different risk scores, only SEDAN and TAG consistently predicted SICH. SEDAN and TAG scores exhibited the highest AUC in predicting SICH for ECASS III (SEDAN 0.72, TAG 0.72) and SITS-MOST (SEDAN 0.73, TAG 0.70) criteria.

CONCLUSION:

Among various risk scores, the TAG and SEDAN scores best predict SICH after EVT. Higher glucose level and unsuccessful recanalization, which are included in the TAG and SEDAN scores, are independent risk factors of SICH in the present cohort, highlighting their detrimental effects.

• Authors: Chuan-Hsiu Fu, Chih-Hao Chen, Chun-Hsien Lin, Chung-Wei Lee, Meng Lee, Sung-Chun Tang, Jiann-Shing Jeng
• Journal: Journal of the Formosan Medical Association = Taiwan yi zhi (J Formos Med Assoc) Vol. 121 Issue 7 Pg. 1257-1265 (Jul 2022) ISSN: 0929-6646 [Print] Singapore
• PMID: 34556379 (Publication Type: Journal Article)
• Copyright: Copyright © 2021. Published by Elsevier B.V.

Chemical References

• Tissue Plasminogen Activator
• Glucose

Topics

• Aged
• Aged, 80 and over
• Brain Ischemia
• Cerebral Hemorrhage (chemically induced)
• Glucose
• Humans
• Male
• Middle Aged
• Risk Factors
• Stroke (etiology)
• Thrombectomy (adverse effects)
• Thrombolytic Therapy
• Tissue Plasminogen Activator (therapeutic use)
• Treatment Outcome