Baesd on previous researches, the natural deep eutectic
solvent (DES) has enormous potential to be used in the fabrication of
hydrogel wound dressing due to its outstanding properties including cytocompatibility, degradability and solubility. In order to further improve the antibaterial capacity of
hydrogel, in the present study
sodium hyaluronate (SH) and the natural DES were utilized to develop a novel
hydrogel wound dressing by
dopamine (DA) coated SH with in situ reduction of
silver nanoparticles (DES-DASH@Ag). Furthermore, during the preparation process, we discovered for the first time that the DES can be used to fill the freeze-dried DASH to prepare a
hydrogel (DES-DASH), which was promising to utilized in the fabrication of other
hydrogels. Besides, the chemical and physical properties as well as wound healing capacity of the DES-DASH@Ag
hydrogel were characterized. As a result, the DES-DASH@Ag
hydrogel presented good cytocompatibility tested using NIH-3 T3 fibroblast cells, and prominent antibacterial effect against two types of bacteria infecting exposed
wound. Furthermore, the
hydrogel facilitated regeneration of mouse skin tissue in the
wound area. The overall performance of DES-DASH@Ag
hydrogel suggested that it could be a promising
wound dressing in modern medicine.