Efficacy of Huaiqihuang granules as adjuvant therapy for bronchial asthma in children: a real-world study.

Abstract

OBJECTIVES:

To study the efficacy of Huaiqihuang granules as adjuvant therapy for bronchial asthma in children.

METHODS:

A multicenter, prospective, and registered real-world study was performed for the children, aged 2-5 years, who had a confirmed diagnosis of bronchial asthma in the outpatient service of 21 hospitals in China. Among these children, the children treated with medications for long-term asthma control (inhaled corticosteroid and/or leukotriene receptor antagonist) without Huaiqihuang granules were enrolled as the control treatment group, and those treated with medications for long-term asthma control combined with Huaiqihuang granules were enrolled as the combined treatment group. The medical data of all children were collected. Outpatient or telephone follow-up was performed at weeks 4, 8, 12, 20, 28, and 36 after treatment, including asthma attacks and rhinitis symptoms. A statistical analysis was performed for the changes in these indices.

RESULTS:

There was no significant difference in the frequency of asthma attacks or rhinitis attacks between the two groups before treatment (P>0.05). After treatment, the combined treatment group had significantly lower frequencies of asthma attacks, severe asthma attacks, and rhinitis attacks compared with the control treatment group (P<0.05). There was no signification difference in the incidence rate of adverse reactions between the two groups (P=0.667).

CONCLUSIONS:

Huaiqihuang granules in addition to medications for long-term asthma control can alleviate the symptoms of bronchial asthma and rhinitis and improve the level of asthma control in children with bronchial asthma, with good safety and little adverse effect. Citation.

• Authors: Hui-Min Wang, Chuan-He Liu, Chang-Shan Liu, Ying Wang, Zhi-Ying Han, Xin Sun, Xing Chen, Shu-Hua An, Muzhapaer Duolikun, Ai-Ping Lu, Min Wang, Yan Cheng, Xiao-Mei Yin, Han-Min Liu, Hong Wang, Shan Hua, Li Dong, Ying Huang, Yi Jiang, Jian-Xin Xiong, Sheng-Gang Ding, Shun-Ying Zhao, Jin-Rong Wang, Gui-Min Huang, Jing-Hui Mu, Yu-Zhi Chen
• Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics (Zhongguo Dang Dai Er Ke Za Zhi) 2021 Sept 15 Vol. 23 Issue 9 Pg. 877-881 ISSN: 1008-8830 [Print] China
• Vernacular Title: 槐杞黄颗粒辅助治疗儿童支气管哮喘疗效的真实世界研究.
• PMID: 34535200 (Publication Type: Journal Article, Multicenter Study)

Chemical References

• Drugs, Chinese Herbal
• huai qi huang

Topics

• Asthma (drug therapy)
• Child
• Drugs, Chinese Herbal (therapeutic use)
• Humans
• Prospective Studies
• Quality of Life