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Research Progress on the Structure and Function of G3BP.

Abstract
Ras-GTPase-activating protein (SH3 domain)-binding protein (G3BP) is an RNA binding protein. G3BP is a key component of stress granules (SGs) and can interact with many host proteins to regulate the expression of SGs. As an antiviral factor, G3BP can interact with viral proteins to regulate the assembly of SGs and thus exert antiviral effects. However, many viruses can also use G3BP as a proximal factor and recruit translation initiation factors to promote viral proliferation. G3BP regulates mRNA translation and attenuation to regulate gene expression; therefore, it is closely related to diseases, such as cancer, embryonic death, arteriosclerosis, and neurodevelopmental disorders. This review discusses the important discoveries and developments related G3BP in the biological field over the past 20 years, which includes the formation of SGs, interaction with viruses, stability of RNA, and disease progression.
AuthorsWeifang Kang, Yue Wang, Wenping Yang, Jing Zhang, Haixue Zheng, Dan Li
JournalFrontiers in immunology (Front Immunol) Vol. 12 Pg. 718548 ( 2021) ISSN: 1664-3224 [Electronic] Switzerland
PMID34526993 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright © 2021 Kang, Wang, Yang, Zhang, Zheng and Li.
Chemical References
  • Poly-ADP-Ribose Binding Proteins
  • RNA Recognition Motif Proteins
  • RNA, Messenger
  • DNA Helicases
  • G3BP1 protein, human
  • RNA Helicases
Topics
  • Animals
  • Cytoplasmic Granules (metabolism)
  • DNA Helicases (chemistry, genetics, metabolism)
  • Gene Expression Regulation
  • Host-Pathogen Interactions
  • Humans
  • Poly-ADP-Ribose Binding Proteins (chemistry, genetics, metabolism)
  • Protein Binding
  • Protein Domains
  • Protein Interaction Domains and Motifs
  • RNA Helicases (chemistry, genetics, metabolism)
  • RNA Recognition Motif Proteins (chemistry, genetics, metabolism)
  • RNA Viruses (physiology)
  • RNA, Messenger (genetics, metabolism)
  • Research
  • Stress, Physiological
  • Structure-Activity Relationship
  • Virus Replication

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