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Chaetocin: A review of its anticancer potentials and mechanisms.

Abstract
Chaetocin is a natural metabolite product with various biological activities and pharmacological functions isolated from Chaetomium species fungi belonging to the thiodiketopyrazines. Numerous studies have demonstrated a wide range of antitumor activities of chaetocin in vitro and in vivo. Several studies have demonstrated that chaetocin suppresses the growth and proliferation of various tumour cells by regulating multiple signalling pathways related to tumour initiation and progression, inducing cancer cell apoptosis (intrinsic and extrinsic), enhancing autophagy, inducing cell cycle arrest, and inhibiting tumour angiogenesis, invasion, and migration. The antitumor effects and molecular mechanisms of chaetocin are reviewed and analysed in this paper, and the prospective applications of chaetocin in cancer prevention and therapy are also discussed. This review aimed to summarize the recent advances in the antitumor activity of chaetocin and to provide a rationale for further exploring the potential application of chaetocin in overcoming cancer in the future.
AuthorsHangyu Jiang, Yuqi Li, Xiaocong Xiang, Zhili Tang, Kang Liu, Qiang Su, Xiaofen Zhang, Lin Li
JournalEuropean journal of pharmacology (Eur J Pharmacol) Vol. 910 Pg. 174459 (Nov 05 2021) ISSN: 1879-0712 [Electronic] Netherlands
PMID34464601 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Biological Products
  • Piperazines
  • chaetocin
Topics
  • Animals
  • Antineoplastic Agents (pharmacology, therapeutic use)
  • Apoptosis (drug effects)
  • Autophagy (drug effects)
  • Biological Products (pharmacology, therapeutic use)
  • Cell Cycle Checkpoints (drug effects)
  • Cell Line, Tumor
  • Cell Movement (drug effects)
  • Chaetomium (chemistry)
  • Disease Models, Animal
  • Humans
  • Neoplasm Invasiveness (pathology, prevention & control)
  • Neoplasms (drug therapy, pathology)
  • Piperazines (pharmacology, therapeutic use)
  • Xenograft Model Antitumor Assays

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