chaetocin

01/01/2021 - "The study establishes a new relationship of Chaetocin and SUV39H1, and paves an avenue for exploring a new strategy to target SUV39H1 by inhibition of Hsp90 in leukemia."
02/01/2013 - "In this study, we demonstrated that treatment with chaetocin enhanced apoptosis in human leukemia HL60, KG1, Kasumi, K562, and THP1 cells. "
04/01/2012 - "We report here that pharmacological inhibition of SUV39H1 by chaetocin induces apoptosis in leukemia cell lines in vitro and primary AML cells ex vivo, and that it interferes with leukemia growth in vivo. "
02/01/2013 - "Importantly, co-treatment with chaetocin and TSA produced potent antileukemic effects in leukemia cells derived from patients. "
04/01/2012 - "Anti-leukemia activity of chaetocin via death receptor-dependent apoptosis and dual modulation of the histone methyl-transferase SUV39H1."

01/01/2019 - "Chaetocin was further found to suppress the growth of gastric cancer xenograft in nude mice. "
01/01/2019 - "Despite not increasing the intercellular ROS levels in gastric cancer cells, chaetocin did cause a reduction in mitochondrial membrane potential probably through its regulation on the expression of Bcl-2 and BAX. "
01/01/2019 - "However, it remains unclear whether the potential indication for chaetocin could also include human gastric cancer. "
01/01/2019 - "Identification of Chaetocin as a Potent non-ROS-mediated Anticancer Drug Candidate for Gastric Cancer."
01/01/2019 - "As chronic and exorbitant ROS levels instigate drug resistance, chaetocin, which eradicates gastric cancer cells without increasing ROS levels, may initiate a new line of non-ROS-mediated anti-tumor strategy."

07/01/2023 - "The present work aims to discover the anticancer potential of the natural compound chaetocin as a therapeutic for lung cancer treatment. "
07/01/2023 - "Results concluded that chaetocin could produce ROS and nuclear damage against A549 lung cancer cells. "
07/01/2023 - "In the future, chaetocin might be an effective bio-safe anticancer agent for lung cancer treatments."
07/01/2023 - "Results showed the significance of chaetocin-induced cell growth inhibition by the expression of G2 /M phase arrest and reactive oxygen species (ROS) dependent apoptosis in A549 lung cancer cells. "
07/01/2023 - "Natural compound chaetocin induced DNA damage and apoptosis through reactive oxygen species-dependent pathways in A549 lung cancer cells and in vitro evaluations."

11/05/2021 - "Several studies have demonstrated that chaetocin suppresses the growth and proliferation of various tumour cells by regulating multiple signalling pathways related to tumour initiation and progression, inducing cancer cell apoptosis (intrinsic and extrinsic), enhancing autophagy, inducing cell cycle arrest, and inhibiting tumour angiogenesis, invasion, and migration. "
02/18/2016 - "Although recent studies have extended the role of chaetocin in tumors, the underlying molecular mechanisms such as the downstream cascade that induces cell death has not clearly been elucidated. "
11/05/2021 - "This review aimed to summarize the recent advances in the antitumor activity of chaetocin and to provide a rationale for further exploring the potential application of chaetocin in overcoming cancer in the future."
01/01/2021 - "Chaetocin also inhibited tumor growth in CRC xenograft models. "
01/01/2021 - "The obtained results support the potential use of natural HKMT inhibitors such as chaetocin or other bioactive compounds in improving radiosensitivity of cancer cells."

02/05/2016 - "In this study, we investigated the inhibitory effect of chaetocin on melanogenesis and the underlying mechanisms in B16F10 mouse melanoma cells. "
01/01/2017 - "These are the first data to demonstrate that chaetocin exerts a proapoptotic activity on human melanoma cells through ROS generation and the intrinsic mitochondrial pathway. "
01/01/2017 - "However, the effect of chaetocin on anti-melanoma pharmacological role has not been investigated. "
01/01/2017 - "Therefore, chaetocin might represent an effective candidate for melanoma chemotherapy."
01/01/2017 - "Therefore, in this study, we explored the effect of chaetocin on cell proliferation in the human melanoma Sk-Mel-28 and A375 cells and the growth of tumor xenografts in nude mice. "