Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and associated with adverse pregnancy outcomes. The aim of this study was to investigate the changes of
lipoprotein-associated phospholipaseA2 (Lp-PLA2) level and its correlation with biochemical indexes in patients with GDM.This observational cross-sectional study was performed among 52 GDM and 48 healthy pregnant women. Automatic biochemical analyzer was employed to test the biochemical indexes, including fasting plasma
glucose (FPG),
Hemoglobin A1c (HbA1c), total
cholesterol (TC),
triglyceride (TG),
high-density lipoprotein cholesterol (HDL-C) and
low-density lipoprotein cholesterol (
LDL-C). The
lipoprotein-associated phospholipaseA2 (Lp-PLA2) level was evaluated by
enzyme-linked
immunosorbent assay, and homeostatic model assessment for
insulin resistance (HOMA-IR) was calculated.The levels of FPG, HbA1c, HOMA-IR, TG, TC and
LDL-C were significantly increased while
high-density lipoprotein cholesterol (HDL-C) level was significantly decreased in the GDM group when compared with those in the control group.
Lp-PLA2 level in maternal blood in the GDM group was significantly higher than that in the control group (199.125 ± 23.494 vs165.825 ± 15.576 ng/mL, P < .05) and logistic regression analysis further confirmed the association of
Lp-PLA2 levels with GDM. Furthermore,
Lp-PLA2 positively correlated with HOMA-IR, TC, and
LDL-C.Our results confirmed the association of
Lp-PLA2 with GDM. This broadens our knowledge on the pathophysiology of GDM and provides insights into the development of new targets for the prevention and treatment of GDM.