Inflammation suppression in doxorubicin-induced cardiotoxicity: natural compounds as therapeutic options.

Abstract

Doxorubicin (DOX) is a potent chemotherapeutic agent; however, the accompanying cardiotoxicity is a significant complication of the usefulness of treatment with DOX. Multiple mechanisms have been suggested for this often fatal side effect, one of which is inflammation. Several pathways with different targets have been reported to result in DOX-induced heart inflammation. Some natural occurring compounds (NCs) have been reported to interact with the DOX-induced cardiotoxicity through targeting one or more of several pathways, including the Nrf2/NF-kB, TLR-4/NF-kB, MAPK/NF-kB, and NLRP3 inflammasome pathways. This article reviews several of these pathways and the potential protective effect of some NCs against the cardiac inflammation induced by DOX.

• Authors: Fatemeh Yarmohammadi, Hedyieh Karbasforooshan, A Wallace Hayes, Gholamreza Karimi
• Journal: Naunyn-Schmiedeberg's archives of pharmacology (Naunyn Schmiedebergs Arch Pharmacol) Vol. 394 Issue 10 Pg. 2003-2011 (10 2021) ISSN: 1432-1912 [Electronic] Germany
• PMID: 34350498 (Publication Type: Journal Article, Review)
• Copyright: © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Chemical References

• Anti-Inflammatory Agents
• Antibiotics, Antineoplastic
• Biological Products
• Doxorubicin

Topics

• Animals
• Anti-Inflammatory Agents (therapeutic use)
• Antibiotics, Antineoplastic (adverse effects)
• Biological Products (therapeutic use)
• Cardiotoxicity (drug therapy)
• Doxorubicin (adverse effects)