Lipoprotein (a) level as a risk factor for stroke and its subtype: A systematic review and meta-analysis.

Abstract

The role of lipoprotein-A [Lp (a)] as a risk factor for stroke is less well documented than for coronary heart disease. Hence, we conducted a systematic review and meta-analysis for the published observational studies in order to investigate the association of Lp (a) levels with the risk of stroke and its subtypes. In our meta-analysis, 41 studies involving 7874 ischemic stroke (IS) patients and 32,138 controls; 13 studies for the IS subtypes based on TOAST classification and 7 studies with 871 Intracerebral hemorrhage (ICH) cases and 2865 control subjects were included. A significant association between increased levels of Lp (a) and risk of IS as compared to control subjects was observed (standardized mean difference (SMD) 0.76; 95% confidence interval (CIs) 0.53-0.99). Lp (a) levels were also found to be significantly associated with the risk of large artery atherosclerosis (LAA) subtype of IS (SMD 0.68; 95% CI 0.01-1.34) as well as significantly associated with the risk of ICH (SMD 0.65; 95% CI 0.13-1.17) as compared to controls. Increased Lp (a) levels could be considered as a predictive marker for identifying individuals who are at risk of developing IS, LAA and ICH.

• Authors: Pradeep Kumar, Priyanka Swarnkar, Shubham Misra, Manabesh Nath
• Journal: Scientific reports (Sci Rep) Vol. 11 Issue 1 Pg. 15660 (08 02 2021) ISSN: 2045-2322 [Electronic] England
• PMID: 34341405 (Publication Type: Journal Article, Meta-Analysis, Systematic Review)
• Copyright: © 2021. The Author(s).

Chemical References

• Lipoprotein(a)

Topics

• Humans
• Lipoprotein(a)
• Stroke