Neurological deterioration in a patient with HIV-associated cryptococcal meningitis initially improving on antifungal treatment: a case report of coincidental racemose neurocysticercosis.

Abstract

BACKGROUND:

Managing HIV-associated cryptococcal meningitis (CM) can become challenging in the presence of concurrent unusual central nervous system infections.

CASE PRESENTATION:

A 58-year old HIV infected woman new ART starter, who was being treated effectively for cryptococcal meningitis, represented with worsening of neurological symptoms. Brain MRI revealed a multicystic lesion in the left temporal lobe. Anti-fungal treatment was escalated for a suspected cryptococcoma, but post-mortem CSF serological test confirmed racemose neurocysticercosis.

CONCLUSION:

Patients with HIV-associated CM are highly immunocompromised and may have multiple pathologies simultaneously. In endemic countries, neurocysticercosis should be considered in the differential diagnosis where there is central nervous system deterioration despite effective therapy for CM.

• Authors: Newton Kalata, Jayne Ellis, Laura Benjamin, Samuel Kampondeni, Peter Chiodini, Thomas Harrison, David G Lalloo, Robert S Heyderman
• Journal: BMC infectious diseases (BMC Infect Dis) Vol. 21 Issue 1 Pg. 724 (Jul 31 2021) ISSN: 1471-2334 [Electronic] England
• PMID: 34332543 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2021. The Author(s).

Chemical References

• Antifungal Agents

Topics

• Antifungal Agents (therapeutic use)
• Female
• HIV Infections (complications, drug therapy)
• Humans
• Magnetic Resonance Imaging
• Meningitis, Cryptococcal (complications, diagnosis, drug therapy)
• Middle Aged
• Neurocysticercosis (complications, drug therapy)