Sulfotransferases (SULTs) are phase II detoxification
enzymes that is involved in the biotransformation of many compounds including tobacco
carcinogens. A polymorphism in the SULT1A1 (Arg213His) gene results in reduced
enzyme activity.We investigated the association between the SULT1A1 (Arg213/His) genotype and
lung cancer (LC). This case-control study comprised of 550 cases and controls, matched on age, gender and smoking status.The variant genotype exhibited no association with LC risk, even after stratification on basis of histological subtypes. Male LC patients carrying the variant His213 allele (p = 0.02) did not exhibit an increased risk towards LC. Smokers harbouring the Arg/His genotype did demonstrate a reduced risk towards LC (AOR = 0.70; p = 0.019). Furthermore, the LC subjects who were heavy smokers and harbouring the Arg/His genotype (AOR = 0.28; p = 0.019) did not show a
genetic predisposition towards LC susceptibility. The subjects who smoked pack years of above 40 and carrying the
His/His (AOR = 0.28; p = 0.036) genotype were found to have a reduced risk for LC. Furthermore, 473 subjects were analysed in regards to overall survival, wherein the
His/His genotype exhibited better OS than
Arg/Arg genotype (11.30 vs. 8.07 months).This study provides evidence of no
genetic predisposition towards LC risk associated with SULT1A1 Arg213His polymorphism in relation to tobacco smoking.