Strong association between insufficient plasma exchange and fatal outcomes in Japanese patients with immune-mediated thrombotic thrombocytopenic purpura.

Abstract

Plasma exchange (PEX) using fresh frozen plasma has considerably reduced the mortality rate in patients with immune-mediated thrombotic thrombocytopenic purpura (iTTP). However, some patients still do not survive even with treatment, but little information is available regarding which treatment these patients received. This study was conducted to obtain this information in 240 patients who met the current iTTP diagnostic criteria and completed at least 30 days of follow-up except for deceased cases. These patients were divided into three groups: survivors (n = 195), TTP-related deaths (n = 32), and other cause of death (n = 13). In the TTP-related death group, 26 of 32 patients experienced sudden death, mostly following radical hypotension and bradycardia. The median follow-up time after admission was 5.0 days, and the median number of PEX sessions was 2.5. Nine patients underwent autopsy and had cardiac microvascular thrombi in arterioles. Levels of lactate dehydrogenase, total bilirubin, serum creatinine, and D-dimer were significantly higher in the TTP-related death group than in the survivors group. Frequent PEX (> 20 sessions) was not associated with TTP-related death. In the acute phase of iTTP, patients with substantial organ damage caused by microthrombi have a greater mortality risk, even after just a few PEX sessions.

• Authors: Michinori Kayashima, Kazuya Sakai, Kazuki Harada, Jun Kanetake, Masayuki Kubo, Eriko Hamada, Masaki Hayakawa, Kinta Hatakeyama, Masanori Matsumoto
• Journal: International journal of hematology (Int J Hematol) Vol. 114 Issue 4 Pg. 415-423 (Oct 2021) ISSN: 1865-3774 [Electronic] Japan
• PMID: 34292506 (Publication Type: Journal Article)
• Copyright: © 2021. Japanese Society of Hematology.

Chemical References

• Biomarkers

Topics

• Biomarkers
• Blood Coagulation
• Blood Coagulation Tests
• Cause of Death
• Health Care Surveys
• Humans
• Immunohistochemistry
• Japan (epidemiology)
• Mortality
• Patient Compliance
• Plasma Exchange (methods, standards)
• Prognosis
• Purpura, Thrombotic Thrombocytopenic (diagnosis, epidemiology, etiology, therapy)
• Treatment Outcome