Osteopontin and galectin-3 as biomarkers of maladaptive right ventricular remodeling in pulmonary hypertension.

Abstract

Aim: This study assessed the utility of osteopontin (OPN) and galectin-3 (Gal-3) as biomarkers of maladaptive right ventricular remodeling in pulmonary hypertension (PH). Materials & methods: We examined plasma levels of OPN and Gal-3 in patients with PH (n = 62), dilated cardiomyopathy (n = 34), left ventricular hypertrophy (LVH; n = 47), and controls without right ventricle (RV) or LV abnormalities (n = 38). Results: OPN and Gal-3 levels were higher in PH, dilated cardiomyopathy and LVH than in the controls. OPN concentrations in PH patients with maladaptive RV were significantly higher than in those with adaptive RV. Gal-3 did not differentiate between adaptive and maladaptive RV remodeling in PH. OPN and Gal-3 levels did not correlate with parameters of LV remodeling. Conclusion: OPN is a potential biomarker of RV maladaptation.

• Authors: Stanislav Keranov, Oliver Dörr, Leili Jafari, Christoph Liebetrau, Till Keller, Christian Troidl, Jessica Riehm, Wiebke Rutsatz, Pascal Bauer, Steffen Kriechbaum, Sandra Voss, Manuel J Richter, Khodr Tello, Henning Gall, Hossein A Ghofrani, Stefan Guth, Werner Seeger, Christian W Hamm, Holger Nef
• Journal: Biomarkers in medicine (Biomark Med) Vol. 15 Issue 12 Pg. 1021-1034 (08 2021) ISSN: 1752-0371 [Electronic] England
• PMID: 34289706 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Galectin 3
• Osteopontin

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers (blood)
• Female
• Galectin 3 (blood)
• Humans
• Hypertension, Pulmonary (blood, diagnosis, physiopathology)
• Hypertrophy, Left Ventricular (blood, diagnosis, physiopathology)
• Male
• Middle Aged
• Osteopontin (blood)
• Sensitivity and Specificity
• Ventricular Dysfunction, Right (blood, diagnosis, physiopathology)
• Ventricular Remodeling (physiology)