Abstract | OBJECTIVES: Concentrations of soluble amyloid precursor proteins-α (sAPPα) and -β (sAPPβ) in cerebrospinal fluid (CSF) may reflect the neuropathology of Alzheimer's disease (AD). We previously reported that the concentrations of both sAPPα and sAPPβ were significantly higher in patients with mild cognitive impairment (MCI) due to AD (MCI-AD) than in control subjects without cognitive impairment. The present study analyzed whether these sAPPs are useful in the differential diagnosis of MCI. METHODS: A modified and sensitive method was used to analyze concentrations of sAPPα and sAPPβ in CSF of patients with MCI-AD (n = 30) and MCI due to other causes (MCI-others) (n = 24). Phosphorylated tau (p-tau) and amyloid β- protein 42 (Aβ42) were also analyzed using standard methods. RESULTS: CSF concentrations of sAPPα and sAPPβ were significantly higher in the MCI-AD than in the MCI-others group (p < 0.001). Furthermore, concentrations of both sAPPα and sAPPβ were highly correlated with the concentration of p-tau, consistent with our previous report. CONCLUSIONS: Measurement of both sAPPs in CSF using sensitive methods can be helpful in the precise differential diagnosis of patients with MCI.
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Authors | Wataru Araki, Kazutomi Kanemaru, Kotaro Hattori, Tadashi Tsukamoto, Yuko Saito, Sumiko Yoshida, Harumasa Takano, Masuhiro Sakata, Yuma Yokoi, Yoshie Omachi, Utako Nagaoka, Masahiro Nagao, Takashi Komori, Hisateru Tachimori, Shigeo Murayama, Hidehiro Mizusawa |
Journal | Aging clinical and experimental research
(Aging Clin Exp Res)
Vol. 34
Issue 2
Pg. 341-347
(Feb 2022)
ISSN: 1720-8319 [Electronic] Germany |
PMID | 34283410
(Publication Type: Journal Article)
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Copyright | © 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG. |
Chemical References |
- APP protein, human
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Biomarkers
- Peptide Fragments
- tau Proteins
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Topics |
- Alzheimer Disease
(cerebrospinal fluid, diagnosis)
- Amyloid beta-Peptides
(cerebrospinal fluid)
- Amyloid beta-Protein Precursor
(cerebrospinal fluid)
- Biomarkers
(cerebrospinal fluid)
- Cognitive Dysfunction
(cerebrospinal fluid, diagnosis)
- Diagnosis, Differential
- Humans
- Peptide Fragments
- tau Proteins
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