Abstract | BACKGROUND AND AIM: METHODS: Using Surveillance, Epidemiology, and End Results (SEER) Program database, we assessed the prevalence of metastasis of early G-NETs and long-term outcomes of ET in G-NET patients with good/moderate differentiation and no muscularis propria (MP) involvement. RESULTS: A total of 2207 patients with stage T1 and T2 G-NETs were included. The depth of invasion into MP [odds ratio (OR) 4.581, 95% confidence interval (CI) 2.571-8.162; P < 0.001] and size of > 20 mm (OR 5.656, 95% CI 2.002-15.975; P = 0.001) were significantly associated with metastasis. The 5-year overall survival (OS) and cancer-specific survival (CSS) of the ET group were similar to the surgery group (91.11% vs. 91.09%, P = 0.750; 99.26% vs. 99.01%, P = 0.173). In the multivariable Cox proportional hazards regression models adjusting for age, gender, race, year of diagnosis, SEER region, depth of tumor invasion, site of cancer, tumor size, and chemotherapy, procedures employed (ET or surgery) had no significant impact on the OS [hazard ratio (HR) 1.189; 95%CI 0.721-1.961; P = 0.498] and CSS (HR 0.684; 95% CI 0.021-22.727; P = 0.832). CONCLUSIONS: The long-term outcome of survival did not appear to differ between ET and surgery in G-NETs with good/moderate differentiation, ≤ 20 mm size, and no MP involvement.
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Authors | Mojin Wang, Shubang Cheng, Lili Zhu, Tao Xu, Jinglin Zhang, Yujie Zhang, Jie Ping, Rui Wang |
Journal | Digestive diseases and sciences
(Dig Dis Sci)
Vol. 67
Issue 7
Pg. 3228-3238
(07 2022)
ISSN: 1573-2568 [Electronic] United States |
PMID | 34272627
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. |
Topics |
- Humans
- Intestinal Neoplasms
(pathology, surgery)
- Neoplasm Metastasis
- Neoplasm Staging
- Neuroendocrine Tumors
(pathology, surgery)
- Pancreatic Neoplasms
(pathology, surgery)
- Prevalence
- Prognosis
- Retrospective Studies
- SEER Program
- Stomach Neoplasms
(pathology, surgery)
- Survival Rate
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