Long non-coding RNAs (
lncRNA) have been identified as key regulators of
tumorigenesis and development. We aim to explore the
biological functions and molecular mechanisms of
lncRNA MIR200CHG in
breast cancer. We found that MIR200CHG is highly expressed in
breast cancer tissues and is related to the
tumor size and histopathological grade. In vitro and in vivo experiments confirmed that MIR200CHG can promote
breast cancer proliferation, invasion, and drug resistance. MIR200CHG directly binds to the
transcription factor Y-box binding protein-1 (YB-1), and inhibits its ubiquitination and degradation. MIR200CHG regulates YB-1 phosphorylation at
serine 102, thereby affecting the expression of genes related to
tumor cell proliferation, apoptosis, invasion, and drug resistance. Additionally, MIR200CHG partially affects the expression of miR-200c/141-3p encoded by its intron region. Therefore, MIR200CHG can promote the proliferation, invasion, and drug resistance of
breast cancer by interacting with and stabilizing YB-1, and has the potential to become a target for
breast cancer treatment.