Upregulation of Fatty Acid Transporters is Associated With Tumor Progression in Non-Muscle-Invasive Bladder Cancer.

Abstract	As patients with non-muscle-invasive bladder cancer (NMIBC) show a high degree of heterogeneity in tumor recurrence or progression, many clinicians demand a detailed risk stratification. Although modified fatty acid metabolism in cancer cells is reported to reflect malignant phenotypes such as metastasis, the impact of fatty acid transporters on NMIBC has never been investigated. This study examined the clinicopathologic implications of fatty acid transporters such as fatty acid transport protein 4 (FATP4), cluster of differentiation 36/fatty acid translocase (CD36/FAT), and long chain acyl CoA synthetase 1 (ACSL1) in 286 NMIBC cases. This study revealed that FATP4, CD36, and ACSL1 were overexpressed in 123 (43.0%), 43 (15.0%), and 35 (12.2%) NMIBC cases, respectively. High FATP4 in tumor cells was associated with high grade (p = 0.004) and high stage (p = 0.039). High CD36 was related to high grade (p < 0.001), high stage (p = 0.002), and non-papillary growth type (p = 0.004). High ACSL1 showed an association with high grade (p < 0.001), high stage (p = 0.01), non-papillary growth type (p = 0.002), and metastasis (p = 0.033). High FATP4 was an independent factor predicting short overall survival (OS) (hazard ratio = 3.32; 95% confidence interval, 1.07-10.31; p = 0.038). In conclusion, upregulation of FATP4, CD36, and ACSL1 might promote the NMIBC progression and could be exploited in clinical risk stratification and targeted therapy.
Authors	Hoiseon Jeong, Hwa Eun Oh, Hyesun Kim, Ju-Han Lee, Eung Seok Lee, Young-Sik Kim, Jung-Woo Choi
Journal	Pathology oncology research : POR (Pathol Oncol Res) Vol. 27 Pg. 594705 ( 2021) ISSN: 1532-2807 [Electronic] Switzerland
PMID	34257543 (Publication Type: Journal Article)
Copyright	Copyright © 2021 Jeong, Oh, Kim, Lee, Lee, Kim and Choi.
Chemical References	CD36 Antigens CD36 protein, human Fatty Acid Transport Proteins SLC27A4 protein, human Coenzyme A Ligases ACSL1 protein, human
Topics	Adult Aged Aged, 80 and over CD36 Antigens (metabolism) Coenzyme A Ligases (metabolism) Fatty Acid Transport Proteins (metabolism) Female Humans Male Middle Aged Prognosis Up-Regulation Urinary Bladder Neoplasms (metabolism, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!