Abstract | OBJECTIVES: METHODS: This cost-effectiveness analysis was performed as a long-term simulation using the Markov model from the Japanese public healthcare payer's perspective. The analysis was conducted using loxoprofen with real-world weighted price by branded/generic distribution (hereinafter, loxoprofen with weighted price) as a comparator. In the model, we simulated the prognosis of patients with chronic pain by OA, RA, and LBP treated with loxoprofen or celecoxib, over a lifetime period. RESULTS: A cost-increase of 129,688 JPY (1,245.00 USD) for branded celecoxib and a cost-reduction of 6,268 JPY (60.17 USD) for AG celecoxib were recognized per patient in lifetime horizon, compared to loxoprofen with weighted price. No case was recognized to reverse the results of cost-saving by AG celecoxib in one-way sensitivity analysis. The incremental cost-effectiveness ratio of branded celecoxib attained 5,403,667 JPY/QALY (51,875.20 USD/QALY), compared to loxoprofen with the weighted price. CONCLUSION: The current cost-effectiveness analysis for AG celecoxib revealed its good value for costs, considering the patients' future risk of gastrointestinal injury; also, the impact on costs due to AG celecoxib against loxoprofen will be small. It implies that the disadvantage of AG celecoxib being slightly more expensive than generic loxoprofen could be offset by the good cost-effectiveness during the prognosis.
|
Authors | Yusuke Karasawa, Isao Kamae, Kazutaka Nozawa, Shigeki Zeniya, Tatsunori Murata, Satoshi Soen, Choitsu Sakamoto |
Journal | PloS one
(PLoS One)
Vol. 16
Issue 7
Pg. e0253547
( 2021)
ISSN: 1932-6203 [Electronic] United States |
PMID | 34228745
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Drugs, Generic
- Phenylpropionates
- loxoprofen
- Celecoxib
|
Topics |
- Aged
- Aged, 80 and over
- Celecoxib
(administration & dosage, adverse effects, economics)
- Chronic Pain
(diagnosis, drug therapy)
- Computer Simulation
- Cost Savings
(statistics & numerical data)
- Cost-Benefit Analysis
- Drug Costs
- Drugs, Generic
(administration & dosage, adverse effects, economics)
- Female
- Gastrointestinal Diseases
(chemically induced, economics, epidemiology)
- Humans
- Japan
- Male
- Markov Chains
- Middle Aged
- Models, Economic
- Phenylpropionates
(administration & dosage, adverse effects, economics)
- Quality-Adjusted Life Years
- Risk Assessment
(statistics & numerical data)
|