Unravelling the link between phthalate exposure and endometriosis in humans: a systematic review and meta-analysis of the literature.
|
| Abstract | PURPOSE:
Endometriosis is a chronic debilitating inflammatory pathology which interests females in their reproductive age. Its pathogenesis has not yet been clearly defined. Recent evidence linked chemical agents as endocrine-disrupting chemicals to endometriosis. Phthalates are a widely used class of such compounds. This study aimed to summarize the current literature evaluating the link between exposure to phthalates and occurrence of endometriosis. METHODS: A systematic review of literature and meta-analysis has been carried out following PRISMA guidelines to assess such link. Fourteen studies have been included in the review. Risk of bias has been assessed through the Newcastle Ottawa Scale. RESULTS: We observed association between endometriosis and increased urinary levels of MBP/MnBP, MEOHP, and MEHHP, but not for others. Blood-derived analysis showed statistically significant link between endometriosis and BBP, DEHP, DnBP, and MEHP. CONCLUSION: Given the wide heterogeneity of included studies, results should be taken with caution. Further studies with more rigorous methodology are encouraged to unravel the true link between this class of toxic compounds and manifestation of endometriosis.
|
|---|---|
| Authors | Alessandro Conforti, Luigi Carbone, Vittorio Simeon, Paolo Chiodini, Vincenzo Marrone, Francesca Bagnulo, Federica Cariati, Ida Strina, Carlo Alviggi |
| Journal | Journal of assisted reproduction and genetics (J Assist Reprod Genet) Vol. 38 Issue 10 Pg. 2543-2557 (Oct 2021) ISSN: 1573-7330 [Electronic] Netherlands |
| PMID | 34227050 (Publication Type: Journal Article, Meta-Analysis, Systematic Review) |
| Copyright | © 2021. The Author(s). |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!