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Development of hydrofluoric acid-cleaned silicon nitride implants for periprosthetic infection eradication and bone regeneration enhancement.

Abstract
Orthopedic implant is commonly associated with occurrence or relapse of osteomyelitis. This study developed a hydrofluoric acid (HF) cleaned silicon nitride (Si3N4) implant Si3N4_AC for osteomyelitis control and established a rat tibial osteomyelitis model to evaluate its efficacy on eradicating periprosthetic infection and enhancing bone regeneration. In vitro studies revealed Si3N4_AC had improved biocompatibility and inhibited Staphylococcus aureus adhesion. A custom-made Si3N4_AC implant was prepared and inserted into the rat tibia longitudinal cavity inoculated with Staphylococcus aureus. The in vivo bacteriostatic and osteogenic efficacies of Si3N4_AC implant were evaluated by histological, microbiological and Micro-CT analyses and compared with implants of pure Ti and Si3N4 . Si3N4_AC implant group revealed 99.5% inhibition of periprosthetic Staphylococcus aureus compared to the osteomyelitis group after 14 days post-operation. Implant-adhering bacteria density of Si3N4_AC was also much lower than pure Ti and Si3N4. In addition, micro-CT evaluation of peri-implant bone formation under the condition of periprosthetic osteomyelitis after 30 days post-surgery confirmed the osteogenic ability of Si3N4_AC. Taken together, Si3N4_AC can be an effective orthopedic biomaterial to eradicate periprosthetic infection and enhance bone regeneration.
AuthorsHuan Zhou, Shaofeng Yang, Donglei Wei, Chunyong Liang, Qiang Yang, Huilin Yang, Donghui Wang, Mingjun Li, Lei Yang
JournalMaterials science & engineering. C, Materials for biological applications (Mater Sci Eng C Mater Biol Appl) Vol. 127 Pg. 112241 (Aug 2021) ISSN: 1873-0191 [Electronic] Netherlands
PMID34225881 (Publication Type: Journal Article)
CopyrightCopyright © 2021 Elsevier B.V. All rights reserved.
Chemical References
  • Anti-Bacterial Agents
  • Silicon Compounds
  • silicon nitride
  • Hydrofluoric Acid
Topics
  • Animals
  • Anti-Bacterial Agents (pharmacology)
  • Bone Regeneration
  • Disease Models, Animal
  • Hydrofluoric Acid
  • Osteomyelitis (drug therapy)
  • Prostheses and Implants
  • Rats
  • Silicon Compounds (pharmacology)
  • Staphylococcal Infections (drug therapy)

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