Azetidines of pharmacological interest.

Abstract

Azetidines are almost unexplored among nitrogen-containing saturated heterocycles due to difficulties associated with their synthesis. However, over the past few years, attempts have been made by scientists to advance their synthetic feasibility. Compounds with the azetidine moiety display an important and diverse range of pharmacological activities, such as anticancer, antibacterial, antimicrobial, antischizophrenic, antimalarial, antiobesity, anti-inflammatory, antidiabetic, antiviral, antioxidant, analgesic, and dopamine antagonist activities, and are also useful for the treatment of central nervous system disorders and so forth. Owing to its satisfactory stability, molecular rigidity, and chemical and biological properties, azetidine has emerged as a valuable scaffold and it has drawn the attention of medicinal researchers. The present review sheds light on the traditional method of synthesis of azetidine and advancements in synthetic methodology over the past few years, along with its application with various examples, and its biological significance.

• Authors: Deepa R Parmar, Jigar Y Soni, Ramakrishna Guduru, Rahul H Rayani, Rakesh V Kusurkar, Anand G Vala
• Journal: Archiv der Pharmazie (Arch Pharm (Weinheim)) Vol. 354 Issue 11 Pg. e2100062 (Nov 2021) ISSN: 1521-4184 [Electronic] Germany
• PMID: 34184778 (Publication Type: Journal Article, Review)
• Copyright: © 2021 Deutsche Pharmazeutische Gesellschaft.

Chemical References

• Azetidines

Topics

• Animals
• Azetidines (chemistry, pharmacology)
• Drug Development (methods)
• Drug Stability
• Humans
• Structure-Activity Relationship