Efficacy Of Different Dosage Regimens Of Carbimazole In The Treatment Of Primary Hyperthyroidism.

Abstract

OBJECTIVES:

To compare the efficacy of Single dose with Divided dose regimen of Carbimazole for the induction of Euthyroidism in hyperthyroid patients.

METHODS:

All consecutive hyperthyroidism patients from December 2018 to December 2019 fulfilling the inclusion criteria were included. They were allocated randomly into 2 groups: Group A - single dose of Carbimazole (OD-CMZ) and Group B - divided dose of Carbimazole (DD-CMZ). The therapeutic efficacy was measured at regular intervals (every 4 weeks) for 6 months. Their demographics and therapeutic management were analysed.

RESULTS:

Of a total of 69 (n=34 in Group A, n=35 in Group B) patients, there was no significant difference in baseline concentrations of TSH and T4 as well as their cumulative rate of reductions (p-value, 0.023). Furthermore, no difference in achieving euthyroidism was noted at follow-up visits between Group A and B respectively ([0:0%; p-value 1.00, month 1], [70.6:74.3%; p value 0.22, month 2], [85.3:85.7%; p value 0.39, month 3], 97.1:82.9%; p-value 0.23, month 4], [100:91.4%; p-value 0.29, month 5], [100:100%%; p value 1.00, month 6] at monthly intervals. Cases of Hypothyroidism were reported more in the DD-CMZ (14.3%) and the difference was statistically significant (p-value 0.003).

CONCLUSIONS:

Due to no significant difference in the efficacy and more chances of getting hypothyroid in divided dose regimen, we conclude that single dose regimen is more effective method for treating hyperthyroidism.

• Authors: Rashid Usman, Shafaq Ismail, Rimsha Tahir, Muhammad Jamil
• Journal: Journal of Ayub Medical College, Abbottabad : JAMC (J Ayub Med Coll Abbottabad) 2021 Apr-Jun Vol. 33 Issue 2 Pg. 244-247 ISSN: 1819-2718 [Electronic] Pakistan
• PMID: 34137538 (Publication Type: Journal Article)

Chemical References

• Antithyroid Agents
• Carbimazole

Topics

• Adult
• Antithyroid Agents (therapeutic use)
• Carbimazole (administration & dosage)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Female
• Humans
• Hyperthyroidism (drug therapy)
• Male
• Middle Aged