What Is the Optimal Irrigation Solution in the Management of Periprosthetic Hip and Knee Joint Infections?

Abstract

BACKGROUND:

Thorough irrigation and debridement using an irrigation solution is a well-established treatment for both acute and chronic periprosthetic joint infections (PJIs). In the absence of concrete data, identifying the optimal irrigation agent and protocol remains challenging.

METHODS:

A thorough review of the current literature on the various forms of irrigations and their additives was performed to evaluate the efficacy and limitations of each solution as pertaining to pathogen eradication in the treatment of PJI. As there is an overall paucity of high-quality literature comparing irrigation additives to each other and to any control, no meta-analyses could be performed. The literature was therefore summarized in this review article to give readers concise information on current irrigation options and their known risks and benefits.

RESULTS:

Antiseptic solutions include povidone-iodine, chlorhexidine gluconate, acetic acid, hydrogen peroxide, sodium hypochlorite, hypochlorous acid, and preformulated commercially available combination solutions. The current literature suggests that intraoperative use of antiseptic irrigants may play a role in treating PJI, but definitive clinical studies comparing antiseptic to no antiseptic irrigation are lacking. Furthermore, no clinical head-to-head comparisons of different antiseptic irrigants have identified an optimal irrigation solution.

CONCLUSION:

Further high-quality studies on the optimal irrigation additive and protocol for the management of PJI are warranted to guide future evidence-based decisions.

• Authors: Ahmed Siddiqi, Zuhdi E Abdo, Stephen R Rossman, Michael A Kelly, Nicolas S Piuzzi, Carlos A Higuera, Ran Schwarzkopf, Bryan D Springer, Antonia F Chen, Javad Parvizi
• Journal: The Journal of arthroplasty (J Arthroplasty) Vol. 36 Issue 10 Pg. 3570-3583 (Oct 2021) ISSN: 1532-8406 [Electronic] United States
• PMID: 34127346 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2021 Elsevier Inc. All rights reserved.

Chemical References

• Anti-Infective Agents, Local
• Povidone-Iodine

Topics

• Anti-Infective Agents, Local
• Humans
• Knee Joint
• Povidone-Iodine
• Prosthesis-Related Infections (drug therapy)
• Therapeutic Irrigation