Abstract | INTRODUCTION: METHODS: RESULTS: 159 patients were identified as diagnosed with an anaplastic oligodendroglioma between 1996 and 2016. Of those, 40 patients were found to have AO at original diagnosis and had documented 1p19q co-deletion with a median of 7.1 years of follow-up (range: 0.6-16.7 years). After surgery, 45 % of patients were treated with radiation and chemotherapy at diagnosis, and 50 % were treated with adjuvant chemotherapy alone. The group treated with chemotherapy alone had a trend of receiving more cycles of chemotherapy than patients treated with radiation and chemotherapy upfront (p = 0.051). Median overall survival has not yet been reached. The related risk of progression in the upfront, adjuvant chemotherapy only group was almost 5-fold higher than the patients who received radiation and chemotherapy (hazard ratio = 4.85 (1.74-13.49), p = 0.002). However, there was no significant difference in overall survival in patients treated with upfront chemotherapy compared to patients treated upfront with chemotherapy and radiation (p = 0.8). Univariate analysis of age, KPS, extent of resection, or upfront versus delayed radiation was not associated with improved survival. CONCLUSIONS:
|
Authors | Nancy Ann Oberheim Bush, Jacob S Young, Yalan Zhang, Cecilia L Dalle Ore, Annette M Molinaro, Jennie Taylor, Jennifer Clarke, Michael Prados, Steve E Braunstein, David R Raleigh, Susan M Chang, Mitchel S Berger, Nicholas A Butowski |
Journal | Journal of neuro-oncology
(J Neurooncol)
Vol. 153
Issue 3
Pg. 447-454
(Jul 2021)
ISSN: 1573-7373 [Electronic] United States |
PMID | 34125374
(Publication Type: Journal Article, Randomized Controlled Trial)
|
Copyright | © 2021. The Author(s). |
Topics |
- Astrocytoma
- Brain Neoplasms
(genetics, therapy)
- Humans
- Oligodendroglioma
(genetics, therapy)
- Retrospective Studies
|