Abstract | OBJECTIVE: To examine the association between neonatal cranial ultrasound ( CUS) abnormalities among infants born extremely preterm and neurodevelopmental outcomes at 10 years of age. STUDY DESIGN: In a multicenter birth cohort of infants born at <28 weeks of gestation, 889 of 1198 survivors were evaluated for neurologic, cognitive, and behavioral outcomes at 10 years of age. Sonographic markers of white matter damage (WMD) included echolucencies in the brain parenchyma and moderate to severe ventricular enlargement. Neonatal CUS findings were classified as intraventricular hemorrhage (IVH) without WMD, IVH with WMD, WMD without IVH, and neither IVH nor WMD. RESULTS: WMD without IVH was associated with an increased risk of cognitive impairment (OR 3.5, 95% CI 1.7, 7.4), cerebral palsy (OR 14.3, 95% CI 6.5, 31.5), and epilepsy (OR 6.9; 95% CI 2.9, 16.8). Similar associations were found for WMD accompanied by IVH. Isolated IVH was not significantly associated these outcomes. CONCLUSIONS: Among children born extremely preterm, CUS abnormalities, particularly those indicative of WMD, are predictive of neurodevelopmental impairments at 10 years of age. The strongest associations were found with cerebral palsy.
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Authors | Heather Campbell, Jennifer Check, Karl C K Kuban, Alan Leviton, Robert M Joseph, Jean A Frazier, Laurie M Douglass, Kyle Roell, Elizabeth N Allred, Lynn Ansley Fordham, Stephen R Hooper, Hernan Jara, Nigel Paneth, Irina Mokrova, Hongyu Ru, Hudson P Santos Jr, Rebecca C Fry, T Michael O'Shea |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 237
Pg. 197-205.e4
(10 2021)
ISSN: 1097-6833 [Electronic] United States |
PMID | 34090894
(Publication Type: Journal Article, Multicenter Study)
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Copyright | Copyright © 2021 Elsevier Inc. All rights reserved. |
Topics |
- Age Factors
- Cerebral Intraventricular Hemorrhage
(complications, diagnostic imaging, therapy)
- Child
- Cohort Studies
- Critical Care
- Echoencephalography
- Female
- Hospitalization
- Humans
- Infant, Extremely Premature
- Infant, Newborn
- Infant, Premature, Diseases
(diagnostic imaging, therapy)
- Leukoencephalopathies
(complications, diagnostic imaging, therapy)
- Male
- Neurodevelopmental Disorders
(diagnosis, epidemiology)
- United States
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