Abstract | AIMS: METHODS: A total of 1,471 patients with type 2 diabetes were enrolled. Fundus radiography was used for DR measurement. AGEs were detected through non-invasive skin autofluorescence method. RESULTS: Patients with more advanced DR showed a much higher AGEs, and the prevalence of DR (based on the severity) increase with ascending AGEs quartiles (all P for trend < 0.001). The multivariable-adjusted odds ratios of any DR across AGEs quartiles were 1.00, 1.69 (95% confidence interval [CI] 1.16-2.47), 1.58 (95%CI 1.06-2.37) and 1.60 (95%CI 1.05-2.44) (P for trend = 0.044), respectively. Similar results were found in vision-threatening DR (VTDR) subgroup (P for trend = 0.009). When AGEs was considered as a continuous variable by using restricted cubic splines, a graded positive association of AGEs with the odds of any presence of DR was observed (P for trend < 0.001). Further, we found that AGEs presented the similar predictive value for any DR with glycated hemoglobin A1c (HbA1c). When it comes to VTDR, AGEs showed a significantly higher efficacy in early screening than HbA1c (P = 0.002). With a cut-off point of 77.1, the sensitivity, specificity and area under the curve of AGEs were 90.0% (95%CI 76.3-97.2%), 49.4% (95%CI 46.8-52.0%), and 0.728 (95%CI 0.704-0.750), respectively. CONCLUSION: Non-invasive measured skin AGEs, associated with the prevalence of all stages of DR, might be a more suitable indicator than HbA1c for mimicking the poor prognosis of hyperglycemia.
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Authors | Lingwen Ying, Yun Shen, Yang Zhang, Yikun Wang, Yong Liu, Jun Yin, Yufei Wang, Jingrong Yin, Wei Zhu, Yuqian Bao, Jian Zhou |
Journal | Diabetes research and clinical practice
(Diabetes Res Clin Pract)
Vol. 177
Pg. 108880
(Jul 2021)
ISSN: 1872-8227 [Electronic] Ireland |
PMID | 34058298
(Publication Type: Journal Article)
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Copyright | Copyright © 2021 Elsevier B.V. All rights reserved. |
Chemical References |
- Glycated Hemoglobin A
- Glycation End Products, Advanced
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Topics |
- Cross-Sectional Studies
- Diabetes Mellitus, Type 2
(complications, epidemiology)
- Diabetic Retinopathy
(diagnosis, epidemiology, etiology)
- Glycated Hemoglobin
(analysis)
- Glycation End Products, Advanced
- Humans
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