Abstract | OBJECTIVES: METHODS: Sixty-five CHB patients were divided into responder and non-responder groups according to whether hepatitis B e antigen seroconversion occurred at week 48. Serum microRNAs were dynamically detected. RESULTS: At baseline, the responder group had lower miR-122-5p (P = 0.006) and higher miR-1307-3p (P = 0.018) than the non-responder group. After therapy, miR-320a-3p and miR-320c were higher in the responder group than the non-responder group (P = 0.043 and 0.031, respectively). In the responder group, 9 microRNAs-let-7d-5p, let-7f-5p, let-7i-5p, miR-126-3p, miR-1307-3p, miR-181a-5p, miR-21-5p, miR-425-5p and miR-652-3p-were significantly lower at week 48 than at baseline (P < 0.05); however, miR-320a-3p was significantly elevated after therapy (P < 0.001). In the non-responder group, miR-122-5p significantly decreased after therapy compared with baseline (P = 0.005). Finally, miR-122-5p was positively correlated with titer of hepatitis B virus DNA (r = 0.438, P = 0.008) and hepatitis B e antigen (r = 0.610, P < 0.001), and miR-320a-3p was negatively correlated with hepatitis B virus DNA titer (r = -0.366, P = 0.028) at baseline. CONCLUSIONS:
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Authors | Bingqin Tan, Mei Liu, Liming Wang, Jinhuan Wang, Fang Xiong, Xuli Bao, Yao Gao, Lele Yu, Jun Lu |
Journal | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
(Int J Infect Dis)
Vol. 108
Pg. 37-44
(Jul 2021)
ISSN: 1878-3511 [Electronic] Canada |
PMID | 33992764
(Publication Type: Journal Article)
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Copyright | Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved. |
Chemical References |
- Antiviral Agents
- Hepatitis B e Antigens
- MicroRNAs
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Topics |
- Antiviral Agents
(therapeutic use)
- Hepatitis B e Antigens
- Hepatitis B, Chronic
(drug therapy)
- Humans
- MicroRNAs
(genetics)
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