Abstract | BACKGROUND: METHODS: This meta-analysis was conducted to assess the effects of carotenoids on overweight or obese subjects utilizing the available evidence. We searched PubMed, Medline, Cochrane Library, Web of Science and EMBASE databases up to September 2020. Random effects models were used to calculate the standard mean differences (SMDs) and odds ratios ( ORs) with their 95% confidence intervals (95% CIs). RESULTS: A total of seven randomized controlled trials and eight observational studies met the inclusion criteria and contained 28 944 subjects and data on multiple carotenoid subgroups, including lycopene, astaxanthin, cryptoxanthin, α- carotene, and β- carotene. In all included Randomized Controlled Trial (RCT), the intervention duration was 20 days at the shortest and 16 weeks at the longest, and the range of intervention doses was 1.2-60 mg d-1. Our study found that the insufficiency of serum carotenoids was a risk factor for overweight and obesity (OR = 1.73, 95% CI [1.57, 1.91], p < 0.001). Moreover, carotenoid supplementation was significantly associated with body weight reductions (SMD = -2.34 kg, 95% CI [-3.80, -0.87] kg, p < 0.001), body mass index decrease (BMI, SMD = -0.95 kg cm-2, 95% CI [-1.88, -0.01] kg cm-2, p < 0.001) and waist circumference losses (WC, SMD = -1.84 cm, 95% CI [-3.14, -0.54]cm, p < 0.001). CONCLUSION: In summary, the carotenoids show promising effects in overweight or obese subjects. Additional data from large clinical trials are needed.
|
Authors | Nan Yao, Shoumeng Yan, Yinpei Guo, Han Wang, Xiaotong Li, Ling Wang, Wenyu Hu, Bo Li, Weiwei Cui |
Journal | Food & function
(Food Funct)
Vol. 12
Issue 11
Pg. 4768-4782
(Jun 08 2021)
ISSN: 2042-650X [Electronic] England |
PMID | 33977977
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
|
Chemical References |
- Cryptoxanthins
- beta Carotene
- Carotenoids
- alpha-carotene
|
Topics |
- Animals
- Body Mass Index
- Body Weight
- Carotenoids
(pharmacology, therapeutic use)
- Cryptoxanthins
- Databases, Factual
- Dietary Supplements
- Humans
- Obesity
(drug therapy)
- Overweight
(drug therapy)
- Waist Circumference
- Weight Loss
- beta Carotene
|