Nanotheranostics, which can provide great insight into
cancer therapy, has been deemed as a promising technology to settle the unmet medical needs. The rational design of high performance nanotheranostics with multiple complementary imaging features and satisfactory therapeutic efficacy is particularly valuable. Herein, versatile nanotheranostic agents DPPB-Gd-I NPs were fabricated by using
gadolinium-diethylenetriaminepentaacetic
acid chelates and an
iodine-decorated copolymer as encapsulation matrixes to encapsulate a
polymer DPPB through one-step nanoprecipitation. We have demonstrated that such nanoagents are able to efficiently damage
tumors under single dose injection and NIR
laser illumination conditions due to the enhanced
photodynamic therapy and enhanced
photothermal therapy (the
tumor inhibition rate was as high as 94.5%). Moreover, these nanoagents can be utilized as dual-modal NIR-II fluorescence/magnetic resonance imaging probes for
tumor diagnosis with high sensitivity, deep tissue penetration, and excellent spatial resolution. Overall, this work offers a powerful tactic to fabricate high performance nanotheranostics for clinical application.