Abstract |
In this study, a novel tumor-targeting drug delivery system (DDS) based on red blood cells (RBCs) were fabricated for combinational chemo- phototherapy against cancer. Cyclic peptide (cRGD) and indocyanine green (ICG) were applied to the surface of RBCs to increase the targeting and photothermal effect, respectively. Doxorubicin (DOX) as a model drug was loaded into RBCs by the hypotonic dialysis method. A series of tests have been carried out to evaluate the RBCs-based DDS and these tasks include physicochemical properties, cellular uptake, targeting ability, and combination therapeutic efficiency. As a result, the DOX was successfully loaded into RBCs and the drug loading amount was 0.84 ± 0.09 mg/mL. There was no significant change of particle size after surface modification of RBCs. The RBCs-based DDS could target to the surface of cancer cells, which delivery DOX to the lesions efficiently and accurately. Meanwhile, due to the combined treatment effect, the RBCs-based DDS can effectively inhibit tumor growth. The RBCs-based DDS constructed in this research may have promising applications in cancer therapy due to their highly synergistic efficient therapy and to investigate its possibility for tumor therapy.
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Authors | Chen Wang, Jingru Huang, Yan Zhang, Hongxin Jia, Binbin Chen |
Journal | Colloids and surfaces. B, Biointerfaces
(Colloids Surf B Biointerfaces)
Vol. 204
Pg. 111789
(Aug 2021)
ISSN: 1873-4367 [Electronic] Netherlands |
PMID | 33932889
(Publication Type: Journal Article)
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Copyright | Copyright © 2021 Elsevier B.V. All rights reserved. |
Chemical References |
- Pharmaceutical Preparations
- Doxorubicin
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Topics |
- Cell Line, Tumor
- Doxorubicin
(pharmacology)
- Drug Delivery Systems
- Drug Liberation
- Erythrocytes
- Hyperthermia, Induced
- Nanoparticles
- Pharmaceutical Preparations
- Phototherapy
- Photothermal Therapy
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