Abstract | BACKGROUND: METHODS: We retrospectively analyzed 11 patients with histopathologically diagnosed choroid plexus carcinoma between January 2008 and December 2016. They were treated with surgical resection with or without adjuvant therapies. The clinical profiles and outcomes were analyzed. RESULTS: The mean age at diagnosis was 16.0 years (median, 7.0 years; range, 4 months to ∼59 years). Gross total resection was achieved in 9 cases, and subtotal resection in 2 cases. Seven patients received adjuvant radiotherapy, and 2 patients underwent chemotherapy. The mean overall survival was 34.8 months, and the mean progression-free survival was 24.5 months. During the follow-up period, 4 patients succumbed to central nervous system dissemination of choroid plexus carcinoma including 2 patients with malignant transformation from atypical choroid plexus papilloma to choroid plexus carcinoma and 1 patient treated with the combined chemotherapy protocol. CONCLUSIONS: In this study, we described the clinicoradiologic characteristics of choroid plexus carcinomas. Surgical resection is the mainstream treatment. Due to the paucity of clinical evidence, the standard regimen of adjuvant therapies still needs further research.
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Authors | Bao Yang, Nijia Zhang, Tao Jiang, Jiang Du, Raynald Liu, Shuqing Yu, Shuo Wang, Chunde Li |
Journal | World neurosurgery
(World Neurosurg)
Vol. 152
Pg. e45-e50
(08 2021)
ISSN: 1878-8769 [Electronic] United States |
PMID | 33892166
(Publication Type: Journal Article)
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Copyright | Copyright © 2021 Elsevier Inc. All rights reserved. |
Topics |
- Adolescent
- Adult
- Carcinoma
(diagnostic imaging, mortality, surgery)
- Child
- Child, Preschool
- Choroid Plexus Neoplasms
(diagnostic imaging, mortality, surgery)
- Cohort Studies
- Female
- Follow-Up Studies
- Humans
- Infant
- Male
- Middle Aged
- Survival Rate
(trends)
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