Abstract |
To improve the fixation of the prosthesis-bone interface and to prevent postoperative infection, a novel antimicrobial hydrogel coating is designed as the biological fixation interface of the artificial joint prosthesis. Antimicrobial chitosan (CS) and gelatine (GT) were used as bioinks to print a CS-GT hydrogel coating with reticulated porous structure on the titanium alloy substrate by 3D printing technology. The experimental results show that the 7CS-10GT hydrogel coating has a macro-grid structure and honeycomb micro-network structure, excellent hydrophilicity (35.64°), high mechanical strength (elastic modulus 0.92 MPa) and high bonding strength (3.36 MPa) with the titanium alloy substrate. In addition, the antimicrobial effect of 7CS-10GT hydrogel against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) is enhanced after immersion in nano‑silver. Moreover, the 7CS-10GT hydrogel displays good cell compatibility and supports proliferation of NIH-3 T3 cells. In summary, the 3D printed CS-GT antimicrobial hydrogel coating provides an ideal microenvironment for cell adhesion and bone growth due to the dual-scale porous network structure, good hydrophilicity and biocompatibility, thus promoting rapid fixation of the bone interface. This technology opens a new possibility for this biological fixation interface in artificial joint replacement.
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Authors | Xiaofang Wu, Siyu Liu, Kai Chen, Fengyan Wang, Cunao Feng, Linmin Xu, Dekun Zhang |
Journal | International journal of biological macromolecules
(Int J Biol Macromol)
Vol. 182
Pg. 669-679
(Jul 01 2021)
ISSN: 1879-0003 [Electronic] Netherlands |
PMID | 33857509
(Publication Type: Journal Article)
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Copyright | Copyright © 2021 Elsevier B.V. All rights reserved. |
Chemical References |
- Anti-Bacterial Agents
- Coated Materials, Biocompatible
- Hydrogels
- Gelatin
- Chitosan
- Titanium
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Topics |
- Animals
- Anti-Bacterial Agents
(chemistry)
- Cell Adhesion
- Cell Proliferation
- Chitosan
(analogs & derivatives)
- Coated Materials, Biocompatible
(chemistry, pharmacology)
- Elastic Modulus
- Gelatin
(chemistry)
- Hydrogels
(chemistry)
- Joint Prosthesis
- Mice
- NIH 3T3 Cells
- Printing, Three-Dimensional
- Staphylococcus aureus
(drug effects)
- Titanium
(chemistry)
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