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3D printed chitosan-gelatine hydrogel coating on titanium alloy surface as biological fixation interface of artificial joint prosthesis.

Abstract
To improve the fixation of the prosthesis-bone interface and to prevent postoperative infection, a novel antimicrobial hydrogel coating is designed as the biological fixation interface of the artificial joint prosthesis. Antimicrobial chitosan (CS) and gelatine (GT) were used as bioinks to print a CS-GT hydrogel coating with reticulated porous structure on the titanium alloy substrate by 3D printing technology. The experimental results show that the 7CS-10GT hydrogel coating has a macro-grid structure and honeycomb micro-network structure, excellent hydrophilicity (35.64°), high mechanical strength (elastic modulus 0.92 MPa) and high bonding strength (3.36 MPa) with the titanium alloy substrate. In addition, the antimicrobial effect of 7CS-10GT hydrogel against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) is enhanced after immersion in nano‑silver. Moreover, the 7CS-10GT hydrogel displays good cell compatibility and supports proliferation of NIH-3 T3 cells. In summary, the 3D printed CS-GT antimicrobial hydrogel coating provides an ideal microenvironment for cell adhesion and bone growth due to the dual-scale porous network structure, good hydrophilicity and biocompatibility, thus promoting rapid fixation of the bone interface. This technology opens a new possibility for this biological fixation interface in artificial joint replacement.
AuthorsXiaofang Wu, Siyu Liu, Kai Chen, Fengyan Wang, Cunao Feng, Linmin Xu, Dekun Zhang
JournalInternational journal of biological macromolecules (Int J Biol Macromol) Vol. 182 Pg. 669-679 (Jul 01 2021) ISSN: 1879-0003 [Electronic] Netherlands
PMID33857509 (Publication Type: Journal Article)
CopyrightCopyright © 2021 Elsevier B.V. All rights reserved.
Chemical References
  • Anti-Bacterial Agents
  • Coated Materials, Biocompatible
  • Hydrogels
  • Gelatin
  • Chitosan
  • Titanium
Topics
  • Animals
  • Anti-Bacterial Agents (chemistry)
  • Cell Adhesion
  • Cell Proliferation
  • Chitosan (analogs & derivatives)
  • Coated Materials, Biocompatible (chemistry, pharmacology)
  • Elastic Modulus
  • Gelatin (chemistry)
  • Hydrogels (chemistry)
  • Joint Prosthesis
  • Mice
  • NIH 3T3 Cells
  • Printing, Three-Dimensional
  • Staphylococcus aureus (drug effects)
  • Titanium (chemistry)

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