Abstract | BACKGROUND: RESULTS: Our paper demonstrates a largely unchanged microbiota profile during 4 weeks of phage therapy when added to systemic antibiotics in a single patient with Staphylococcus aureus device infection. Metabolomic analyses suggest potential indirect cascading ecological impacts to the host (skin) microbiome. We did not detect genomes of the three phages used to treat the patient in metagenomic samples taken from saliva, stool, and skin; however, phages were detected using endpoint-PCR in patient serum. CONCLUSION: Results from our proof-of-principal study supports the use of bacteriophages as a microbiome-sparing approach to treat bacterial infections. Video abstract.
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Authors | Andre Mu, Daniel McDonald, Alan K Jarmusch, Cameron Martino, Caitriona Brennan, Mackenzie Bryant, Gregory C Humphrey, Julia Toronczak, Tara Schwartz, Dominic Nguyen, Gail Ackermann, Anthony D'Onofrio, Steffanie A Strathdee, Robert T Schooley, Pieter C Dorrestein, Rob Knight, Saima Aslam |
Journal | Microbiome
(Microbiome)
Vol. 9
Issue 1
Pg. 92
(04 14 2021)
ISSN: 2049-2618 [Electronic] England |
PMID | 33853672
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Video-Audio Media)
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Chemical References |
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Topics |
- Anti-Bacterial Agents
(therapeutic use)
- Bacteriophages
(genetics)
- Humans
- Microbiota
- Phage Therapy
- Staphylococcal Infections
(drug therapy)
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