Abstract | PURPOSE: METHODS: Retrospective case series of patients presenting with catastrophic antiphospholipid syndrome and posterior segment ocular manifestations. The main outcomes were the type of posterior segment manifestations at catastrophic antiphospholipid syndrome diagnosis, specifically retinal vascular occlusion, vasculitis, or choroidopathy, and the final best-corrected visual acuity. RESULTS: This study included 23 patients (11 cases treated by the authors and 12 published case reports); 21 (91%) of them female. Their median age at diagnosis was 28 years (range, 16-79 years). Ophthalmologic manifestations were usually bilateral (n = 19, 83%) and involved vascular occlusive retinopathy (n = 17, 74%), choroidopathy (n = 11, 48%), or retinal vasculitis (n = 1, 4%). Final best-corrected visual acuity was not significantly worse than the best-corrected visual acuity at diagnosis (P = 0.16). Retinal vascular occlusions were associated with poorer final visual acuity than choroidopathy (P = 0.002). After a median follow-up of 14 months (range, 2-132 months), nearly half the patients (n = 11, 48%) had permanent vision loss including best-corrected visual acuity of <20/400 for 4 patients. CONCLUSION:
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Authors | Nathalie Morel, Clémence Bonnet, Hanane Mehawej, Véronique Le Guern, Laurent Pérard, Mathilde Roumier, Antoine Brezin, Bertrand Godeau, Julien Haroche, Ygal Benhamou, Marc Lambert, Cécile M Yelnik, Nicolas Maillard, Bahram Bodaghi, Jean-Charles Piette, Nathalie Costedoat-Chalumeau |
Journal | Retina (Philadelphia, Pa.)
(Retina)
Vol. 41
Issue 11
Pg. 2332-2341
(Nov 01 2021)
ISSN: 1539-2864 [Electronic] United States |
PMID | 33840791
(Publication Type: Case Reports, Journal Article, Review)
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Topics |
- Adolescent
- Adult
- Aged
- Antiphospholipid Syndrome
(complications)
- Female
- Fluorescein Angiography
(methods)
- Fundus Oculi
- Humans
- Male
- Middle Aged
- Retrospective Studies
- Severity of Illness Index
- Tomography, Optical Coherence
(methods)
- Vision Disorders
(diagnosis, etiology)
- Visual Acuity
- Young Adult
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