Abstract | BACKGROUND: The role of progestogens in colorectal cancer development is poorly characterized. To address this, our group developed a highly sensitive assay to measure concentrations of seven markers of endogenous progestogen metabolism among postmenopausal women. METHODS: The markers were measured in baseline serum collected from postmenopausal women in a case-cohort study within the breast and bone follow-up to the fracture intervention trial (B∼FIT). We followed women not using exogenous hormones at baseline (1992-1993) for up to 12 years: 187 women with incident colorectal cancer diagnosed during follow-up and a subcohort of 495 women selected on strata of age and clinical center. We used adjusted Cox regression models with robust variance to estimate risk for colorectal cancer [hazard ratios (HR), 95% confidence intervals (CI)]. RESULTS: CONCLUSIONS: IMPACT: Our findings are consistent with most prior research on circulating endogenous sex hormones, which taken together suggest that sex hormones may not be major drivers of colorectal carcinogenesis in postmenopausal women.
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Authors | Kara A Michels, Ashley M Geczik, Doug C Bauer, Louise A Brinton, Diana S M Buist, Jane A Cauley, Cher M Dallal, Roni T Falk, Trisha F Hue, James V Lacey Jr, Andrea Z LaCroix, Jeffrey A Tice, Xia Xu, Britton Trabert |
Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
(Cancer Epidemiol Biomarkers Prev)
Vol. 30
Issue 6
Pg. 1100-1105
(06 2021)
ISSN: 1538-7755 [Electronic] United States |
PMID | 33827983
(Publication Type: Journal Article, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)
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Copyright | ©2021 American Association for Cancer Research. |
Chemical References |
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Topics |
- Aged
- Carcinogenesis
(metabolism)
- Case-Control Studies
- Colorectal Neoplasms
(epidemiology, metabolism)
- Female
- Follow-Up Studies
- Humans
- Incidence
- Middle Aged
- Postmenopause
(blood, metabolism)
- Progestins
(blood, metabolism)
- Prospective Studies
- Risk Factors
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