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Pregnenolone

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A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.

Also Known As:

5-Pregnen-3-beta-ol-20-one; 5 Pregnen 3 beta ol 20 one; Pregn-5-en-20-one, 3-hydroxy-, (3beta)-

Networked: 201 relevant articles (1 outcomes, 23 trials/studies) for this Bio-Agent, Comments

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Bio-Agent Context: Research Results

Experts

1.	Marx, Christine E: 4 articles (07/2009 - 06/2006)
2.	Shampine, Lawrence J: 3 articles (07/2009 - 06/2006)
3.	Morrow, A Leslie: 3 articles (07/2009 - 06/2006)
4.	Lieberman, Jeffrey A: 3 articles (07/2009 - 06/2006)
5.	Butterworth, Roger F: 3 articles (03/2008 - 05/2005)
6.	Trost, William T: 3 articles (08/2006 - 06/2006)
7.	Massing, Mark W: 3 articles (08/2006 - 06/2006)
8.	Costa, Barbara: 2 articles (12/2009 - 05/2008)
9.	Hamer, Robert M: 2 articles (07/2009 - 06/2006)
10.	Bradford, Daniel W: 2 articles (07/2009 - 08/2006)

Related Diseases

1.	Rheumatoid Arthritis 11/13/1953 - "[Pregnenolone in rheumatoid arthritis; study in 18 cases with this steroid.]" 12/01/1951 - "Further observations on the use of pregnenolone in rheumatoid arthritis." 11/01/1951 - "The clinical effects of delta 5 pregnenolone in rheumatoid arthritis." 09/01/1951 - "[Experience with pregnenolone in rheumatoid arthritis.]" 07/19/1951 - "[Therapeutic essay with synthetic pregnenolone in a case of rheumatoid arthritis.]" Order ALL the reference details at left...
2.	Glioma (Gliomas) 06/01/1992 - "Pregnenolone synthesis in intact C6-2B glioma cells was stimulated by nanomolar concentrations of 4'CD after 5 min of incubation with MVA. " 03/17/1998 - "C6 rat glioma tumor cells in culture biosynthesize both pregnenolone (P) and D. " 01/03/2008 - "The aim of this study was to investigate the regulation of expression of the steroid sulfotransferase SULT2B1a, which catalyzes the conversion of pregnenolone to PREGS, using the rat C6 glioma cell line. " 10/01/1993 - "A subset of these ligands was also shown to stimulate pregnenolone formation from the mitochondria of C6-2B glioma cells with an EC50 of about 3 nM. In animal experiments ligands selected for further study were found to exhibit antineophobic effects, in spite of the fact that they exhibit no direct action on GABAA receptors. " 05/01/2008 - "The in vitro functional activity of DPA-714 was measured in a steroidogenic assay in which the ability of DPA-714 to increase pregnenolone synthesis was measured with rat C6 glioma cells. " Order ALL the reference details at left...
3.	Neoplasms (Cancer) 09/01/1987 - "The Y-1 mouse adrenocortical tumor cells secrete into the culture medium some metabolites of pregnenolone. " 03/17/1998 - "C6 rat glioma tumor cells in culture biosynthesize both pregnenolone (P) and D. " 01/01/1984 - "Steroidogenesis in a histologically and ultrastructurally clearly defined Sertoli-Leydig cell tumor ( androblastoma ) was studied by incubation of tumor slices with tritiated and unlabeled pregnenolone. " 10/01/1982 - "The tumor was cultured in vitro and shown by high performance liquid chromatography (HPLC) to produce predominantly DOC from tritiated pregnenolone, with no detectable aldosterone, in agreement with the in vivo results." 01/01/1980 - "Isolated guinea pig adrenal cortical cells were incubated with the various separated form of mouse tumor cell ACTH and products synthesized from (3H)pregnenolone were analyzed by two-dimensional thin-layer chromatography. " Order ALL the reference details at left...
4.	Schizophrenia (Dementia Praecox) 07/01/2009 - "Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia." 04/01/2007 - "Further research into the role of pregnenolone in schizophrenia is warranted." 04/01/2007 - "CONCLUSION: Low serum pregnenolone concentrations in schizophrenia appear to be associated with trait-anxiety scores independent of symptoms. " 07/01/2009 - "Pregnenolone may be a promising therapeutic agent for negative symptoms and merits further investigation for cognitive symptoms in schizophrenia." 01/01/2010 - "Pregnenolone, dehydroepiandrosterone, and schizophrenia: alterations and clinical trials." Order ALL the reference details at left...
5.	Phobic Disorders (Phobia) 07/01/2002 - "RESULTS: Concentrations of pregnenolone sulphate were significantly lower in patients with generalized social phobia than in healthy controls. " 07/01/2002 - "Low pregnenolone sulphate plasma concentrations in patients with generalized social phobia." 11/15/2005 - "In the present study we measured the circulatory [corrected] levels of DHEA, DHEA-S, pregnenolone and cortisol in [corrected] untreated patients (n=26) diagnosed with social phobia (SP) compared with sex- and age-matched healthy controls (n=21). " 07/01/2002 - "This study compared plasma levels of allopregnanolone, dehydroepiandrosterone sulphate and pregnenolone sulphate in healthy controls and in patients with generalized social phobia, as assessed with the Mini-International Neuropsychiatric Interview. " 07/01/2002 - "METHODS: Plasma concentrations of allopregnanolone, pregnenolone sulphate, and dehydroepiandrosterone sulphate were measured in 12 unmedicated male patients with generalized social phobia and 12 matched healthy male volunteers. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Cortisone
2.	Dehydroepiandrosterone (DHEA)
3.	Steroids
4.	Cholesterol
5.	Testosterone (Sustanon)
6.	Hydrocortisone (Cortisol)
7.	Pregnanolone (Allopregnanolone)
8.	Progesterone
9.	Androstenedione (4 Androstene 3,17 dione)
10.	17-alpha-Hydroxyprogesterone (17 Hydroxyprogesterone)

Related Therapies and Procedures

1.	Orchiectomy (Orchidectomy)
2.	Castration
3.	Aftercare (After-Treatment)

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