Abstract |
Outcomes of patients with multiple myeloma (MM) who become refractory to standard therapies are particularly poor and novel agents are greatly needed to improve outcomes in such patients. B-cell maturation antigen ( BCMA) has become an important therapeutic target in MM with three modalities of treatment in development including antibody-drug conjugates (ADCs), bispecific T-cell engagers ( BITEs), and chimeric antigen receptor (CAR) T-cell therapies. Early clinical trials of anti- BCMA immunotherapeutics have demonstrated extremely promising results in heavily pretreated patients with relapsed/refractory MM (RRMM). Recently, belantamab mafodotin was the first anti- BCMA therapy to obtain approval in relapsed/refractory MM. This review summarizes the most updated efficacy and safety data from clinical studies of BCMA-targeted therapies with a focus on ADCs and BITEs. Additionally, important differences among the BCMA-targeted treatment modalities and their clinical implications are discussed.
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Authors | Larysa Sanchez, Alexandra Dardac, Deepu Madduri, Shambavi Richard, Joshua Richter |
Journal | Therapeutic advances in hematology
(Ther Adv Hematol)
Vol. 12
Pg. 2040620721989585
( 2021)
ISSN: 2040-6207 [Print] England |
PMID | 33796236
(Publication Type: Journal Article, Review)
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Copyright | © The Author(s), 2021. |