Antibody responses to the BNT162b2 mRNA vaccine in individuals previously infected with SARS-CoV-2.

Abstract	In a cohort of BNT162b2 (Pfizer-BioNTech) mRNA vaccine recipients (n = 1,090), we observed that spike-specific IgG antibody levels and ACE2 antibody binding inhibition responses elicited by a single vaccine dose in individuals with prior SARS-CoV-2 infection (n = 35) were similar to those seen after two doses of vaccine in individuals without prior infection (n = 228). Post-vaccine symptoms were more prominent for those with prior infection after the first dose, but symptomology was similar between groups after the second dose.
Authors	Joseph E Ebinger, Justyna Fert-Bober, Ignat Printsev, Min Wu, Nancy Sun, John C Prostko, Edwin C Frias, James L Stewart, Jennifer E Van Eyk, Jonathan G Braun, Susan Cheng, Kimia Sobhani
Journal	Nature medicine (Nat Med) Vol. 27 Issue 6 Pg. 981-984 (06 2021) ISSN: 1546-170X [Electronic] United States
PMID	33795870 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References	Antibodies, Neutralizing Antibodies, Viral Antigens, Viral COVID-19 Vaccines Coronavirus Nucleocapsid Proteins Immunoglobulin G Immunoglobulin M Phosphoproteins Spike Glycoprotein, Coronavirus nucleocapsid phosphoprotein, SARS-CoV-2 spike protein, SARS-CoV-2 ACE2 protein, human Angiotensin-Converting Enzyme 2 BNT162 Vaccine
Topics	Adult Angiotensin-Converting Enzyme 2 (metabolism) Antibodies, Neutralizing (immunology) Antibodies, Viral (biosynthesis, immunology) Antibody Specificity Antigens, Viral (immunology) BNT162 Vaccine COVID-19 (immunology) COVID-19 Vaccines (adverse effects, immunology) Convalescence Coronavirus Nucleocapsid Proteins (immunology) Female Health Personnel Humans Immunization, Secondary (adverse effects) Immunoglobulin G (biosynthesis, immunology) Immunoglobulin M (biosynthesis, immunology) Immunologic Memory Male Middle Aged Phosphoproteins (immunology) SARS-CoV-2 (immunology) Spike Glycoprotein, Coronavirus (immunology) Symptom Assessment Vaccination

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!