T2 mapping in gadoxetic acid-enhanced MRI: utility for predicting decompensation and death in cirrhosis.

Abstract

OBJECTIVES:

To determine whether T2 mapping in liver MRI can predict decompensation and death in cirrhotic patients.

METHODS:

This retrospective study included 292 cirrhotic patients who underwent gadoxetic acid-enhanced MRI, including T1 and T2 mapping at 10-min hepatobiliary phase by using the Look-Locker and radial turbo spin-echo sequences, respectively. T1 and T2 values of the liver and spleen were measured. The association of MR parameters and serum markers with decompensation and death was investigated. Risk models combining T2Liver, serum albumin level, and Model for End-Stage Liver Disease (MELD) score were created for predicting decompensation (T2Liver, < 49.3 versus ≥ 49.3 ms) and death (< 57.4 versus ≥ 57.4 ms).

RESULTS:

In patients with compensated cirrhosis at baseline and in the full patient cohort, 9.6% (19 of 197) and 5.1% (15 of 292) developed decompensation and died during the mean follow-up periods of 18.7 and 19.2 months, respectively. A prolonged T2Liver (hazard ratio (HR), 2.59; 95% confidence interval (CI), 1.26, 5.31) was independently predictive of decompensation along with the serum albumin level (HR, 0.28; 95% CI, 0.12, 0.68) and MELD score (HR, 1.34; 95% CI, 1.08, 1.66). T2Liver (HR, 2.61; 95% CI, 1.19, 5.72) and serum albumin level (HR, 0.46; 95% CI, 0.19, 1.14) were independent predictors of death. The mean times to decompensation (12.9 versus 29.2 months) and death (16.5 versus 29.6 months) were significantly different between the high- and low-risk groups (p < 0.001).

CONCLUSION:

T2Liver from T2 mapping can predict decompensation and death in patients with cirrhosis.

KEY POINTS:

• Liver T2 values from the radial turbo spin-echo (TSE) T2 mapping sequence with tiered echo sharing and pseudo golden-angle (pGA) reordering were significantly higher in decompensated cirrhosis than compensated cirrhosis. • Liver T2 values from the radial TSE T2 mapping sequence with tiered echo sharing and pGA reordering can predict decompensation and death in patients with cirrhosis. • T2 mapping is recommended as part of liver MRI examinations for cirrhotic patients because it can provide a noninvasive prognostic marker for the development of decompensation and death.

• Authors: Wonjeong Yang, Ji Eun Kim, Ho Cheol Choi, Mi Jung Park, Hye Young Choi, Hwa Seon Shin, Jeong Ho Won, Fei Han, Marcel Dominik Nickel, Hyun Chin Cho
• Journal: European radiology (Eur Radiol) Vol. 31 Issue 11 Pg. 8376-8387 (Nov 2021) ISSN: 1432-1084 [Electronic] Germany
• PMID: 33782768 (Publication Type: Journal Article)
• Copyright: © 2021. European Society of Radiology.

Chemical References

• gadolinium ethoxybenzyl DTPA
• Gadolinium DTPA

Topics

• End Stage Liver Disease
• Gadolinium DTPA
• Humans
• Liver Cirrhosis (complications, diagnostic imaging)
• Magnetic Resonance Imaging
• Retrospective Studies
• Severity of Illness Index