Evaluation of dysfunctional high-density lipoprotein levels with myeloperoxidase/paraoxonase-1 ratio in rheumatoid arthritis.

Abstract

BACKGROUND:

The aim of this study is to evaluate dysfunctional high-density lipoprotein cholesterol (HDL) by measuring myeloperoxidase (MPO)/paraoxonase 1 (PON1) ratio in patients with rheumatoid arthritis (RA) and to investigate the relationship between dysfunctional HDL and cardiovascular disease (CVD) in RA patients.

METHODS:

Sixty-seven healthy individuals and 130 RA patients were included in the study. Routine lipid panels (triglyceride (TG), low-density lipoprotein cholesterol (LDL), HDL, total cholesterol (TC), PON1 and MPO levels were measured. Disease activity scores-28 (DAS28) of RA patients were calculated. Cardiological examination records of the patients were assessed to detect patients who also have CVD.

RESULTS:

There were no significant differences between RA and control groups in routine lipid profiles (P > .05 for all). MPO/PON1 ratios were significantly elevated in the RA group compared with the control group (P < .001). MPO/PON1 ratios were higher in RA patients with CVD history compared with those without CVD (P < .05). MPO/PON1 ratios were correlated with DAS28 scores (rho: 0.357, P < .001).

CONCLUSION:

HDL dysfunction determined by the MPO/PON1 ratio may be associated with the pathophysiology of increased CVD in RA. Thus, evaluating dysfunctional HDL levels by measuring the MPO/PON1 ratio in RA patients may allow more detailed patient follow-up, as well as the reduction of CVD events in RA patients with therapeutic agents aiming to increase the functional properties of HDL by decreasing this ratio.

• Authors: Tugba Alisik, Murat Alisik, Baris Nacir, Fikriye Figen Ayhan, Hakan Genc, Ozcan Erel
• Journal: International journal of clinical practice (Int J Clin Pract) Vol. 75 Issue 7 Pg. e14172 (Jul 2021) ISSN: 1742-1241 [Electronic] India
• PMID: 33756027 (Publication Type: Journal Article)
• Copyright: © 2021 John Wiley & Sons Ltd.

Chemical References

• Lipoproteins, HDL
• Triglycerides
• Peroxidase
• Aryldialkylphosphatase
• PON1 protein, human

Topics

• Arthritis, Rheumatoid (complications)
• Aryldialkylphosphatase
• Humans
• Lipoproteins, HDL
• Peroxidase
• Triglycerides