Abstract | PURPOSE: METHODS: The study group comprised 536 patients with primary breast cancer who underwent NACT followed by immediate IBBR or AFR. After propensity score matching, 138 patients in the IBBR group and 276 patients in the AFR group were selected for comparisons of locoregional recurrence-free survival (LRRFS), disease-free survival (DFS), distant metastasis-free survival (DMFS), and breast cancer-specific survival (BCSS). RESULTS: No significant differences were observed between the matched groups in locoregional recurrence rates (IBBR vs. AFR: 12.3% vs. 12%; P = 0.915) and distant metastasis (13% vs. 17%; P = 0.293). There was also no significant difference between the groups in LRRFS (P = 0.956), DFS (P = 0.606), DMFS (P = 0.283), or BCSS (P = 0.121). The 5- and 10-year LRRFS rates were 87.6% and 85.9% in the IBBR group, and 87.7% and 86.1% in the AFR group; the 5- and 10-year DFS rates were 79% and 77.5% in the IBBR group, and 77% and 75% in the AFR group; the 5- and 10-year DMFS rates were 85.9% and 85.9% in the IBBR group, and 83.2% and 81.8% in the AFR group; and the 5- and 10-year BCSS rates were 97.8% and 91.3% in the IBBR group, and 91.8% and 86% in the AFR group, respectively. CONCLUSIONS: In this propensity score-matched analysis of oncologic outcomes in breast cancer patients who underwent immediate reconstruction after NACT, no significant differences were observed between the IBBR and AFR groups.
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Authors | Zhen-Yu Wu, Hyun Ho Han, Hee Jeong Kim, Jong Won Lee, Il Yong Chung, Jisun Kim, Sae Byul Lee, Byung-Ho Son, Jin Sup Eom, Jae Ho Jung, Sung- Bae Kim, Gyungyub Gong, Hak Hee Kim, Sei -Hyun Ahn, BeomSeok Ko |
Journal | Breast cancer research and treatment
(Breast Cancer Res Treat)
Vol. 187
Issue 2
Pg. 417-425
(Jun 2021)
ISSN: 1573-7217 [Electronic] Netherlands |
PMID | 33740204
(Publication Type: Journal Article)
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Topics |
- Breast Neoplasms
(drug therapy, surgery)
- Female
- Humans
- Mammaplasty
- Mastectomy
- Neoadjuvant Therapy
- Neoplasm Recurrence, Local
(epidemiology, surgery)
- Propensity Score
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