Background and aim:
Vitamin D deficiency is frequently reported in patients with
SARS-CoV-2 infection. The aim of this study was to correlate the 25OH-Vitamin D serum concentrations with clinical parameters of lung involvement, in elderly patients hospitalized for
SARS-CoV-2 infection. Methods: Sixty-five consecutive
COVID-19 patients (mean age 76 ± 13 years) and sixty-five sex- and age-matched control subjects (CNT) were analyzed. The following clinical parameters, including comorbidities, were collected at admission: type of pulmonary involvement, respiratory parameters (PaO2, SO2, PaCO2, PaO2/FiO2), laboratory parameters (including 25OH-
vitamin D,
D-dimer,
C-reactive protein). Results: Significantly lower
vitamin D serum levels were found in
COVID-19 patients than in CNT (median 7.9 vs 16.3 ng/mL, p = 0.001). Interestingly, a statistically significant positive correlation was observed between
vitamin D serum levels and PaO2 (p = 0.03), SO2 (p = 0.05), PaO2/FiO2 (p = 0.02), while a statistically significant negative correlation was found between
vitamin D serum levels and
D-dimer (p = 0.04),
C-reactive protein (p = 0.04) and percentage of O2 in a venturi mask (p = 0.04). A negative correlation was also observed between
vitamin D serum levels and severity of radiologic pulmonary involvement, evaluated by computed tomography: in particular,
vitamin D was found significantly lower in
COVID-19 patients with either multiple lung consolidations (p = 0.0001) or diffuse/severe interstitial lung involvement than in those with mild involvement (p = 0.05). Finally, significantly lower
vitamin D serum levels were found in the elderly
COVID-19 patients who died during hospitalization, compared to those who survived (median 3.0 vs 8.4 ng/mL, p = 0.046). Conclusions: This study confirms that 25OH-vitamin D serum deficiency is associated with more severe lung involvement, longer disease duration and risk of death, in elderly
COVID-19 patients. The detection of low
vitamin D levels also in younger
COVID-19 patients with less comorbidities further suggests
vitamin D deficiency as crucial risk factor at any age.