Protective effects of curcumin on chemical and drug-induced cardiotoxicity: a review.

Abstract

Cardiotoxicity is a major adverse effect that can be induced by both therapeutic agents and industrial chemicals. The pathogenesis of such cardiac damage is multifactorial, often injuring the cardiac tissue by generating free radicals, oxidative stress, and/or inflammation. Curcumin (CUR) is a bright yellow chemical produced by Curcuma longa plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae. Administration of CUR has been reported to ameliorate the chemical and drug-induced cardiac injury in several studies. CUR has been suggested to act as an effective candidate against oxidative stress and inflammation in heart tissue via regulation of Nrf2 and suppression of p38 MAPK/NF-κB and NLRP3 inflammasomes. The anti-apoptotic properties of CUR have also been reported to modulate the AMPK, Akt, JNK, and ERK signaling pathways. This review explores the potential protective effects of CUR regarding the detrimental effects often observed in cardiac tissue following exposure to several chemicals including drugs.

• Authors: Fatemeh Yarmohammadi, A Wallace Hayes, Gholamreza Karimi
• Journal: Naunyn-Schmiedeberg's archives of pharmacology (Naunyn Schmiedebergs Arch Pharmacol) Vol. 394 Issue 7 Pg. 1341-1353 (07 2021) ISSN: 1432-1912 [Electronic] Germany
• PMID: 33666716 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Antibiotics, Antineoplastic
• Cardiotonic Agents
• Curcumin

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology, therapeutic use)
• Antibiotics, Antineoplastic (toxicity)
• Cardiotonic Agents (pharmacology, therapeutic use)
• Cardiotoxicity (metabolism, prevention & control)
• Curcumin (pharmacology, therapeutic use)
• Humans
• Oxidative Stress (drug effects, physiology)